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Open AccessLongitudinal gut virome analysis identifies specific viral signatures that precede necrotizing enterocolitis onset in preterm infants
Necrotizing enterocolitis (NEC) is a serious consequence of preterm birth and is often associated with gut bacterial microbiome alterations. However, little is known about the development of the gut virome in ...
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Article
Open AccessDiscordant transmission of bacteria and viruses from mothers to babies at birth
The earliest microbial colonizers of the human gut can have life-long consequences for their hosts. Precisely how the neonatal gut bacterial microbiome and virome are initially populated is not well understood...
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Article
Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome
Hospitalized preterm infants receive frequent and often prolonged exposures to antibiotics because they are vulnerable to infection. It is not known whether the short-term effects of antibiotics on the preterm...
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Article
Open AccessIntestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis
Necrotizing enterocolitis (NEC) is a catastrophic disease of preterm infants, and microbial dysbiosis has been implicated in its pathogenesis. Studies evaluating the microbiome in NEC and preterm infants lack ...
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Article
Developmental dynamics of the preterm infant gut microbiota and antibiotic resistome
Development of the preterm infant gut microbiota is emerging as a critical research priority1. Since preterm infants almost universally receive early and often extended antibiotic therapy2, it is important to und...
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Open AccessErratum: Gut resistome development in healthy twin pairs in the first year of life
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Article
Open AccessGut resistome development in healthy twin pairs in the first year of life
The early life of the human host marks a critically important time for establishment of the gut microbial community, yet the developmental trajectory of gut community-encoded resistance genes (resistome) is un...