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Open AccessPrenatal exposure to maternal disadvantage-related inflammatory biomarkers: associations with neonatal white matter microstructure
Prenatal exposure to heightened maternal inflammation has been associated with adverse neurodevelopmental outcomes, including atypical brain maturation and psychiatric illness. In mothers experiencing socioeco...
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Article
Open AccessSocial and psychological adversity are associated with distinct mother and infant gut microbiome variations
Health disparities are driven by underlying social disadvantage and psychosocial stressors. However, how social disadvantage and psychosocial stressors lead to adverse health outcomes is unclear, particularly ...
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Article
Open AccessSocial disadvantage during pregnancy: effects on gestational age and birthweight
Whether psychosocial adversity during pregnancy impacts fetal health outcomes at birth remains underexplored. This is a critical issue given significant social disadvantage and psychosocial stress faced by pre...
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Open AccessLongitudinal gut virome analysis identifies specific viral signatures that precede necrotizing enterocolitis onset in preterm infants
Necrotizing enterocolitis (NEC) is a serious consequence of preterm birth and is often associated with gut bacterial microbiome alterations. However, little is known about the development of the gut virome in ...
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Article
Factors associated with progression to infection in methicillin-resistant Staphylococcus aureus-colonized, critically ill neonates
To identify factors associated with development of symptomatic infection in infants colonized with methicillin-resistant Staphylococcus aureus (MRSA) in the Neonatal Intensive Care Unit (NICU).
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Article
Open AccessDiscordant transmission of bacteria and viruses from mothers to babies at birth
The earliest microbial colonizers of the human gut can have life-long consequences for their hosts. Precisely how the neonatal gut bacterial microbiome and virome are initially populated is not well understood...
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Article
Open AccessDeterminants of Initial Antibiotic Duration in Very Low Birth Weight Neonates
Very low birth weight (VLBW) neonates (< 1500 g) are commonly exposed to prolonged antibiotic courses related to concerns for presumed early onset sepsis often with unclear indications. While antibiotics can b...
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Open AccessIntestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis
Necrotizing enterocolitis (NEC) is a catastrophic disease of preterm infants, and microbial dysbiosis has been implicated in its pathogenesis. Studies evaluating the microbiome in NEC and preterm infants lack ...
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Open AccessErratum: Gut resistome development in healthy twin pairs in the first year of life
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Open AccessGut resistome development in healthy twin pairs in the first year of life
The early life of the human host marks a critically important time for establishment of the gut microbial community, yet the developmental trajectory of gut community-encoded resistance genes (resistome) is un...