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Article
Open AccessGliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction
To uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24 Alzheimer’s disease and control brains and focused on vascular a...
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Article
Open AccessLUSTR: a new customizable tool for calling genome-wide germline and somatic short tandem repeat variants
Short tandem repeats (STRs) are widely distributed across the human genome and are associated with numerous neurological disorders. However, the extent that STRs contribute to disease is likely under-estimated...
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Article
CARMA is a new Bayesian model for fine-map** in genome-wide association meta-analyses
Fine-map** is commonly used to identify putative causal variants at genome-wide significant loci. Here we propose a Bayesian model for fine-map** that has several advantages over existing methods, includin...
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Article
Admixture Map** of Alzheimer’s disease in Caribbean Hispanics identifies a new locus on 22q13.1
Late-onset Alzheimer’s disease (LOAD) is significantly more frequent in Hispanics than in non-Hispanic Whites. Ancestry may explain these differences across ethnic groups. To this end, we studied a large cohor...
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Article
Open AccessCorrection: Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation
A correction to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessWhole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation
The Alzheimer’s Disease Sequencing Project (ADSP) undertook whole exome sequencing in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal controls primarily of European ancestry (EA), am...
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Open AccessErratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain
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Open AccessNetwork-driven plasma proteomics expose molecular changes in the Alzheimer’s brain
Biological pathways that significantly contribute to sporadic Alzheimer’s disease are largely unknown and cannot be observed directly. Cognitive symptoms appear only decades after the molecular disease onset, ...
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Article
Open AccessRole of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
P73 belongs to the p53 family of cell survival regulators with the corresponding locus Trp73 producing the N-terminally distinct isoforms, TAp73 and DeltaNp73. Recently, two studies have implicated the murine Trp...
