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Article
Open AccessStructure-based prediction and characterization of photo-crosslinking in native protein–RNA complexes
UV-crosslinking of protein and RNA in direct contacts has been widely used to study protein-RNA complexes while our understanding of the photo-crosslinking mechanisms remains poor. This knowledge gap is due to...
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Article
Correction: Results of Immediate Postpartum Long Acting Reversible Contraception Provision After Expanded Reimbursement Policy Implementation at an Academic Medical Institution
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Article
Results of Immediate Postpartum Long Acting Reversible Contraception Provision After Expanded Reimbursement Policy Implementation at an Academic Medical Institution
Immediate postpartum (IPP) Long Acting Reversible Contraception (LARC) is effective in reducing short birth spacing, which is highest among minoritized and younger women with lower socioeconomic status. The st...
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Article
Optimizing 304 Stainless Steel Surface Performance with CoCrFeMoNi High-Entropy Alloy Coating via Gas Tungsten Arc Cladding
CoCrFeMoNi high entropy alloy (HEA) coatings were fabricated on the surface of the 304 stainless steel (304SS) via argon tungsten arc cladding process. The microstructure, micro-hardness and tribological perfo...
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Article
CARMA is a new Bayesian model for fine-map** in genome-wide association meta-analyses
Fine-map** is commonly used to identify putative causal variants at genome-wide significant loci. Here we propose a Bayesian model for fine-map** that has several advantages over existing methods, includin...
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Article
Open AccessBIGKnock: fine-map** gene-based associations via knockoff analysis of biobank-scale data
We propose BIGKnock (BIobank-scale Gene-based association test via Knockoffs), a computationally efficient gene-based testing approach for biobank-scale data, that leverages long-range chromatin interaction da...
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Article
Open AccessGhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies
Recent advances in genome sequencing and imputation technologies provide an exciting opportunity to comprehensively study the contribution of genetic variants to complex phenotypes. However, our ability to tra...
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Article
Open AccessComprehensive analysis of lncRNA-mRNAs co-expression network identifies potential lncRNA biomarkers in cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinoma (cSCC) is the second most common type of skin cancer, the prognosis for patients with metastatic cSCC remains relatively poor. Thus, there is an urgent need to identify new di...
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Article
Open AccessIdentification of putative causal loci in whole-genome sequencing data via knockoff statistics
The analysis of whole-genome sequencing studies is challenging due to the large number of rare variants in noncoding regions and the lack of natural units for testing. We propose a statistical method to detect...
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Article
Open AccessA semi-supervised approach for predicting cell-type specific functional consequences of non-coding variation using MPRAs
Predicting the functional consequences of genetic variants in non-coding regions is a challenging problem. We propose here a semi-supervised approach, GenoNet, to jointly utilize experimentally confirmed regul...
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Article
Observations on potential novel transcripts from RNA-Seq data
With the rapid development of next generation deep sequencing technologies, sequencing cDNA reverse-transcribed from RNA molecules (RNA-Seq) has become a key approach in studying gene expression and transcript...
