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Article
Unraveling Estrogen and PCSK9’s Roles in Lipid Metabolism Disorders among Ovariectomized Mice
We explore the interaction between estrogen and PCSK9 and their collective impact on lipid metabolism, especially concerning the regulation of low-density lipoprotein receptor levels. Utilizing both animal and...
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Article
Recognition of autism spectrum disorder in children based on electroencephalogram network topology
Although our knowledge of autism spectrum disorder (ASD) has been deepened, the accurate diagnosis of ASD from normal individuals is still left behind. In this study, we proposed to apply the spatial pattern o...
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Article
Open AccessClinical evidence for efficacy of pembrolizumab in MSI-H and TMB-H advanced solid tumor: results from three cancer centers in China
Pembrolizumab has been indicated in the treatment of solid tumors with high frequency microsatellite instability (MSI-H) or high tumor mutational burden (TMB-H); however, real-world data on the effectiveness o...
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Article
Open AccessTh1 cells contribute to retinal ganglion cell loss in glaucoma in a VCAM-1-dependent manner
Glaucoma is a complex neurodegenerative disorder characterized by the progressive loss of retinal ganglion cells (RGC) and optic nerve axons, leading to irreversible visual impairment. Despite its clinical sig...
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Article
Open AccessInterplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas
Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH-mutant astrocytomas, have been im...
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Article
Targeting TBK1 to overcome resistance to cancer immunotherapy
Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment strategies to overcome resistance to cancer immunotherapy are lacking1,2. Here we identify the innate immune kinase TANK-bin...
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Article
Open AccessPathway signatures derived from on-treatment tumor specimens predict response to anti-PD1 blockade in metastatic melanoma
Both genomic and transcriptomic signatures have been developed to predict responses of metastatic melanoma to immune checkpoint blockade (ICB) therapies; however, most of these signatures are derived from pre-...
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Article
Open AccessTargeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF-mutant melanoma
Targeting MAPK pathway using a combination of BRAF and MEK inhibitors is an efficient strategy to treat melanoma harboring BRAF-mutation. The development of acquired resistance is inevitable due to the signaling ...
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Article
Evolution of delayed resistance to immunotherapy in a melanoma responder
Despite initial responses1–3, most melanoma patients develop resistance4 to immune checkpoint blockade (ICB). To understand the evolution of resistance, we studied 37 tumor samples over 9 years from a patient wit...
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Article
Open AccessVery low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy
Several immunotherapy clinical trials in recurrent glioblastoma have reported long-term survival benefits in 10–20% of patients. Here we perform genomic analysis of tumor tissue from recurrent WHO grade IV gli...
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Article
Plasma spray–physical vapor deposition toward advanced thermal barrier coatings: a review
Plasma spray–physical vapor deposition (PS–PVD) is a unique technology that enables highly tailorable functional films and coatings with various rare metal elements to be processed. This technology bridges the...
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Article
Open AccessFunctional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer
Chronic inflammation and chromosome aneuploidy are major traits of primary liver cancer (PLC), which represent the second most common cause of cancer-related death worldwide. Increased cancer fitness and aggre...
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Article
Continuous triangular norm based fuzzy topology
For each continuous t-norm &, a class of fuzzy topological spaces, called &-topological spaces, is introduced. The motivation stems from the idea that to each many-valued logic there may correspond a theory of...
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Article
Open AccessB cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of inflammation center on anti-tumor T cell responses. Here we show that tumor as...
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Article
Fabrication of cellulose nanocrystal composite filter papers for rapid and highly efficient removal of bacteria from aqueous solutions
Cellulose nanocrystal (CNC) composite filter papers were fabricated by a facile method, which consists of the bleaching and hydrolysis of fibers, and drop coating of filter papers with CNC solution. The filter...
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Article
Open AccessAuthor Correction: Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis
The original version of this Article contained an error in the spelling of the author Brett L. Ecker, which was incorrectly given as Brett Ecker. This has now been corrected in both the PDF and HTML versions o...
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Article
Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas
In this Letter, two relevant references were omitted; see the accompanying Amendment for details. The original Letter has not been corrected.
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Article
Open AccessLoss of Phd2 cooperates with BRAFV600E to drive melanomagenesis
Prolyl hydroxylase domain protein 2 (PHD2) is a well-known master oxygen sensor. However, the role of PHD2 in tumor initiation remains controversial. We find that during the transition of human nevi to melanom...
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Article
Publisher Correction: Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma
In the version of this article originally published, there was an error in the URL linked to by an accession code in the data availability section of the methods. The erroneous URL was: https:/...
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Article
Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma
Immune checkpoint blockade (ICB) therapy provides remarkable clinical gains and has been very successful in treatment of melanoma. However, only a subset of patients with advanced tumors currently benefit from...
