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Article
Role of tumour necrosis factor gene polymorphisms (-308 and -238) in breast cancer susceptibility and severity
Genetic polymorphisms in the promoter region of the tumour necrosis factor (TNF) gene can regulate gene expression and have been associated with inflammatory and malignant conditions. We have investigated two ...
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Article
Open AccessIndependent associations of anti-cyclic citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis
Several recent publications have established a strong association between anti-cyclic citrullinated peptide antibody (anti-CCP)-positive rheumatoid arthritis (RA) and carriage of shared epitope (SE) alleles. A...
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Open AccessThe interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis
An important feature of autoimmune diseases is the overlap of pathophysiological characteristics. Clustering of autoimmune diseases in families suggests that genetic variants may contribute to autoimmunity. Th...
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Article
Rheumatoid arthritis association at 6q23
This is an issue edsumm for 32. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence shows that sea surface temperatures near the North Pole increased from roughly 18 degree...
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Article
Open AccessLack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis
A feature of rheumatoid arthritis (RA) is an imbalance between proinflammatory and anti-inflammatory cytokines. Several recent studies have implicated polymorphism in the IL-4 signalling pathway in the develop...
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Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
Jane Worthington and colleagues report that three SNPs, located on chromosomes 10p15, 12q13 and 22q13, are associated with susceptibility to rheumatoid arthritis. These SNPs had previously been putatively asso...
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Complex genetic association of 6q23 with autoimmune rheumatic conditions
In the paper by Dieguez-Gonzalez and colleagues in the present issue of Arthritis Research & Therapy, the results of a detailed genetic investigation of the recently identified rheumatoid arthritis and systemic l...
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Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
Soumya Raychaudhuri and colleagues demonstrate the utility of GRAIL, a software program used to prioritize results from genome-wide association studies for further replication, applied here to rheumatoid arthr...
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Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Eli Stahl and colleagues report results of a genome-wide association study meta-analysis and replication study for rheumatoid arthritis. Their work identifies several new risk loci and highlights genetic overl...
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Open AccessAlterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initia...
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Open AccessOverlap** genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
Genome wide association studies, replicated by numerous well powered validation studies, have revealed a large number of loci likely to play a role in susceptibility to many multifactorial diseases. It is now ...
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Open AccessCorrelation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort
In many European countries, restrictions exist around the prescription of anti-tumor necrosis factor (anti-TNF) treatments for rheumatoid arthritis (RA). Eligibility and response to treatment is assessed by us...
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Open AccessA genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis
Progression of joint destruction in rheumatoid arthritis (RA) is partly heritably; 45 to 58% of the variance in joint destruction is estimated to be explained by genetic factors. The binding of RANKL (Receptor...
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Genetic and epigenetic predictors of responsiveness to treatment in RA
In rheumatoid arthritis (RA), patient responsiveness to the first-line treatment used is the most important predictor of long-term disease outcomes
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Open AccessRheumatoid arthritis response to treatment across IgG1 allotype – anti-TNF incompatibility: a case-only study
We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tum...
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Open AccessGenome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis
Rheumatoid arthritis (RA) is characterised by chronic synovial joint inflammation. Treatment has been revolutionised by tumour necrosis factor alpha inhibitors (TNFi) but each available drug shows a significan...
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Article
Can machine learning predict responses to TNF inhibitors?
A machine learning model to predict whether patients with rheumatoid arthritis will respond to TNF inhibitors has been produced following an international crowd-sourced competition, but is the mixture of clini...
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Open AccessTranscriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment
Despite the success of TNF-inhibitor therapy in rheumatoid arthritis treatment, up to 40% of patients fail to respond adequately. This study aimed to identify transcriptome-based biomarkers of adalimumab respo...
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Article
Open AccessGenetics of chronic nonbacterial osteomyelitis in the irish population: no significant association with rare FBLIM1 variants
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Open AccessVariability in phenotype and response to treatment in chronic nonbacterial osteomyelitis; the Irish experience of a national cohort
Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory disease affecting bone with considerable phenotypic heterogeneity and variable association with other autoinflammatory conditions. Disease pathog...
