20 Result(s)

Article

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis

Rheumatoid arthritis (RA) is characterised by chronic synovial joint inflammation. Treatment has been revolutionised by tumour necrosis factor alpha inhibitors (TNFi) but each available drug shows a significan...

Jonathan Massey, Darren Plant, Kimme Hyrich, Ann W. Morgan… in The Pharmacogenomics Journal (2018)

Article

Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples

Gene expression profiling is rapidly becoming a useful and informative tool in a much needed area of research. Identifying patients as to whether they will respond or not to a given treatment before prescripti...

Samantha Louise Smith, Stephen Eyre, Annie Yarwood… in Arthritis Research & Therapy (2015)

Article

Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation

Giant cell arteritis (GCA) is an autoimmune disease commonest in Northern Europe and Scandinavia. Previous studies report various associations with HLA-DRB1*04 and HLA-DRB1*01; HLA-DRB1 alleles show a gradient in...

Sarah Louise Mackie, John C. Taylor, Lubna Haroon-Rashid… in Arthritis Research & Therapy (2015)

Article

Correction: Corrigendum: Dense genoty** of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

Nature Communications 6: Article number: 6046 (2015); Published 5 February 2015; Updated 6 July 2015 The affiliation details for Emiliano Giardina are incorrect in this Article. The correct address for this au...

John Bowes, Ashley Budu-Aggrey, Ulrike Huffmeier, Steffen Uebe… in Nature Communications (2015)

Article

Rheumatoid arthritis response to treatment across IgG1 allotype – anti-TNF incompatibility: a case-only study

We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tum...

Ariana Montes, Eva Perez-Pampin, Federico Navarro-Sarabia… in Arthritis Research & Therapy (2015)

Article

Dense genoty** of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date ar...

John Bowes, Ashley Budu-Aggrey, Ulrike Huffmeier, Steffen Uebe… in Nature Communications (2015)

Article

Dilatation of the thoracic aorta and increased arterial stiffness is common in patients with giant cell arteritis - preliminary findings from a cardiac magnetic resonance study

Bara Erhayiem, Adam K McDiarmid… in Journal of Cardiovascular Magnetic Resonan… (2015)

Article

Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

In many European countries, restrictions exist around the prescription of anti-tumor necrosis factor (anti-TNF) treatments for rheumatoid arthritis (RA). Eligibility and response to treatment is assessed by us...

Darren Plant, Ibrahim Ibrahim, Mark Lunt, Stephen Eyre… in Arthritis Research & Therapy (2012)

Article

Overlap** genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease

Genome wide association studies, replicated by numerous well powered validation studies, have revealed a large number of loci likely to play a role in susceptibility to many multifactorial diseases. It is now ...

Stephen Eyre, Anne Hinks, John Bowes, Edward Flynn… in Arthritis Research & Therapy (2010)

Article

Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort

This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception co...

Ann W Morgan, James I Robinson, Philip G Conaghan… in Arthritis Research & Therapy (2010)

Article

Association of FCGR2A and FCGR2A-FCGR3Ahaplotypes with susceptibility to giant cell arteritis

The Fc gamma receptors have been shown to play important roles in the initiation and regulation of many immunological and inflammatory processes and to amplify and refine the immune response to an infection. W...

Ann W Morgan, Jim I Robinson, Jennifer H Barrett… in Arthritis Research & Therapy (2006)

Article

Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B

The Fcγ receptors play important roles in the initiation and regulation of many immunological and inflammatory processes, and genetic variants (FCGR) have been associated with numerous autoimmune and infectious d...

Ann W Morgan, Jennifer H Barrett, Bridget Griffiths… in Arthritis Research & Therapy (2005)

Article

Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia

We previously demonstrated prolonged, profound CD4⁺ T-lymphopenia in rheumatoid arthritis (RA) patients following lymphocyte-depleting therapy. Poor reconstitution could result either from reduced de novo T-cell ...

Frederique Ponchel, Robert J Verburg, Sarah J Bingham, Andrew K Brown… in Arthritis Res Ther (2004)