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Article
Open AccessIntranasal vaccine for Lyme disease provides protection against tick transmitted Borrelia burgdorferi beyond one year
Strategies for disease control are necessary to reduce incidence of Lyme Disease (LD) including development of safe vaccines for human use. Parainfluenza virus 5 (PIV5) vector has an excellent safety record in...
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Article
Open AccessCorrection: Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil
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Article
Stable δ13C and δ15N isotope and palynofacies study of the late Miocene to early Pliocene Nicobar Fan sediments, Indian Ocean: implication for organic matter provenance and depositional environment
The sedimentary core (late Miocene to early Pliocene) retrieved from the Nicobar Fan (Site-U1480) was used to determine organic matter provenances, paleodeposition, and paleoclimate conditions on the hinterlan...
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Article
Open AccessDeconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil
Systemic lupus erythematosus (SLE) is a clinically and biologically heterogeneous autoimmune disease. We explored whether the deconvolution of whole blood transcriptomic data could identify differences in pred...
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Navigating the Labyrinths During the Pandemic: Women’s Experiences in Higher Education
World over women’s participation in the workforce has further reduced as a consequence of the ongoing pandemic. In India, the women’s Labour Force Participation is as low as 20.5%, with a majority of women bei...
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Global Higher Education During and Beyond COVID-19: Perspectives and Challenges
The COVID-19 pandemic ushered unprecedented challenges globally. The disruption and damage to human life and organizations caused by the pandemic are global in scale. Though pandemics are not new in human hist...
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Higher Education in a Post-COVID World: Employment, Entrepreneurship and Socio-Economic Mobility
.The chapter examines the role universities can play in enhancing students’ employability, entrepreneurship and socio-economic mobility during and after the Pandemic. It presents the thoughts of expert scholar...
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Article
An updated review on the role of the CXCL8-CXCR1/2 axis in the progression and metastasis of breast cancer
Chronic inflammation is a major factor in tumor growth and progression. Cancer cells secrete C-X-C chemokine ligand 8 (CXCL8) along with its receptor C-X-C chemokine receptor 1 (CXCR1) and chemokine receptor 2...
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Article
Therapeutic opportunities of edible antiviral plants for COVID-19
The pandemic of Serious Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) that produces corona virus disease (COVID-19) has challenged the entire mankind by rapidly spreading globally in 210 countries aff...
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Article
Open AccessCorrection to: Transcriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment
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Open AccessPrediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics
Methotrexate (MTX) is a common first-line treatment for new-onset rheumatoid arthritis (RA). However, MTX is ineffective for 30–40% of patients and there is no way to know which patients might benefit. Here, w...
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Open AccessTranscriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment
Despite the success of TNF-inhibitor therapy in rheumatoid arthritis treatment, up to 40% of patients fail to respond adequately. This study aimed to identify transcriptome-based biomarkers of adalimumab respo...
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Article
Effect of environmental toxicants on neuronal functions
In the last few years, neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD) have attracted attention due to their high prevalence worldwide. Environmental factors may be one of...
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Article
Open AccessProteomic analysis to define predictors of treatment response to adalimumab or methotrexate in rheumatoid arthritis patients
Seropositivity for anti-citrullinated peptide antibodies (ACPA) in patients with rheumatoid arthritis (RA), a chronic autoimmune arthritis, is associated with worse long-term disease outcomes. ACPA is ubiquito...
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Introduction—Scientific Drilling in the Indian Ocean: An Earth System Process Perspective
The International Ocean Discovery Program (IODP) addresses the fundamental questions about Earth’s climate, deep life, geodynamics, and geohazards, through Earth’s climatic, biological, chemical, and geologica...
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Article
Can machine learning predict responses to TNF inhibitors?
A machine learning model to predict whether patients with rheumatoid arthritis will respond to TNF inhibitors has been produced following an international crowd-sourced competition, but is the mixture of clini...
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Article
Open AccessA screening program to test and treat for Helicobacter pylori infection: Cost-utility analysis by age, sex and ethnicity
The World Health Organization recommends all countries consider screening for H. pylori to prevent gastric cancer. We therefore aimed to estimate the cost-effectiveness of a H. pylori serology-based screening pro...
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Article
Open AccessDesigning low-cost “heart healthy bread”: optimization using linear programing and 15-country comparison
Bread is an important component of the diet in many countries and provides needed nutrients but also typically too much of other nutrients e.g., sodium. We therefore aimed to use linear programing to determine...
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Article
Open AccessCancer care coordinators in stage III colon cancer: a cost-utility analysis
There is momentum internationally to improve coordination of complex care pathways. Robust evaluations of such interventions are scarce. This paper evaluates the cost-utility of cancer care coordinators for st...
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Article
Open AccessHow much might a society spend on life-saving interventions at different ages while remaining cost-effective? A case study in a country with detailed data
We aimed to estimate the maximum intervention cost (EMIC) a society could invest in a life-saving intervention at different ages while remaining cost-effective according to a user-specified cost-effectiveness ...
