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Article
Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis
Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to detect genetic signals, fine-map** resolution and per...
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Article
Open AccessHLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status
Haplotypes defined by amino acids at HLA-DRB1 positions 11, 71 and 74 associated with susceptibility to rheumatoid arthritis (RA) are associated with radiological outcome, anti-TNF response and all cause-morta...
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Article
Open AccessApplication of information theoretic feature selection and machine learning methods for the development of genetic risk prediction models
In view of the growth of clinical risk prediction models using genetic data, there is an increasing need for studies that use appropriate methods to select the optimum number of features from a large number of...
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Article
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney
The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and antihypertensive treatment. However, genetically mediated renal mechanisms underlying susceptibility to hypertension ...
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Article
Open AccessGenetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases
Genome-wide association studies (GWAS) have identified pervasive sharing of genetic architectures across multiple immune-mediated diseases (IMD). By learning the genetic basis of IMD risk from common diseases,...
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Article
Open AccessMolecular insights into genome-wide association studies of chronic kidney disease-defining traits
Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcri...
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Article
Open AccessMajor histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis
Genotypic variability based genome-wide association studies (vGWASs) can identify potentially interacting loci without prior knowledge of the interacting factors. We report a two-stage approach to make vGWAS a...
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Article
Correction: Corrigendum: Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls
Nat. Genet. 47, 839–846 (2015); published online 8 June 2015; corrected after print 8 July 2015 In the version of this article initially published, the two panels in Figure 2 were presented in the incorrect or...
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Article
Correction: Corrigendum: Dense genoty** of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
Nature Communications 6: Article number: 6046 (2015); Published 5 February 2015; Updated 6 July 2015 The affiliation details for Emiliano Giardina are incorrect in this Article. The correct address for this au...
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Article
Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls
Mary Fortune, Chris Wallace and colleagues report a new method that allows statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls. They apply thei...
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Article
Open AccessDense genoty** of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date ar...
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Article
Genetics of rheumatoid arthritis contributes to biology and drug discovery
A genome-wide association study meta-analysis of more than 100,000 subjects of European and Asian ancestries reveals 42 new risk loci for rheumatoid arthritis, with follow-up studies identifying 98 biological ...
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Article
Dense genoty** of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
Anne Hinks and colleagues identify 14 new susceptibility loci for juvenile idiopathic arthritis through targeted analyses of genomic regions implicated in immune function. Their study implicates several pathwa...
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Article
High-density genetic map** identifies new susceptibility loci for rheumatoid arthritis
Jane Worthington and colleagues use a high-density genoty** chip to identify new susceptibility loci for rheumatoid arthritis and examine genetic overlap with other autoimmune diseases. Their results increas...
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Article
Open AccessRare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis
Genome-wide association studies (GWAS) conducted using commercial single nucleotide polymorphisms (SNP) arrays have proven to be a powerful tool for the detection of common disease susceptibility variants. How...
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Article
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis
André Reis and colleagues report a genome-wide association study identifying a susceptibility locus at TRAF3IP2 for psoriatic arthritis and psoriasis.
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Article
Open AccessOverlap** genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
Genome wide association studies, replicated by numerous well powered validation studies, have revealed a large number of loci likely to play a role in susceptibility to many multifactorial diseases. It is now ...
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Article
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Eli Stahl and colleagues report results of a genome-wide association study meta-analysis and replication study for rheumatoid arthritis. Their work identifies several new risk loci and highlights genetic overl...
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Article
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
Soumya Raychaudhuri and colleagues demonstrate the utility of GRAIL, a software program used to prioritize results from genome-wide association studies for further replication, applied here to rheumatoid arthr...
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Article
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
Jane Worthington and colleagues report that three SNPs, located on chromosomes 10p15, 12q13 and 22q13, are associated with susceptibility to rheumatoid arthritis. These SNPs had previously been putatively asso...
