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Open AccessProceedings of the 23rd Paediatric Rheumatology European Society Congress: part one
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Dense genoty** of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
Anne Hinks and colleagues identify 14 new susceptibility loci for juvenile idiopathic arthritis through targeted analyses of genomic regions implicated in immune function. Their study implicates several pathwa...
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Open AccessAutoinflammatory gene polymorphisms and susceptibility to UK juvenile idiopathic arthritis
To investigate the autoinflammatory hereditary periodic fever syndrome genes MVK and TNFRSF1A, and the NLRP1 and IL1 genes, for association with juvenile idiopathic arthritis (JIA).
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Open AccessSystemic juvenile idiopathic arthritis is associated with HLA-DRB1 in Europeans and Americans of European descent
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Open AccessSubtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23Rwith juvenile psoriatic arthritis
Juvenile idiopathic arthritis (JIA) is an umbrella term for all chronic childhood arthropathies and can be divided into seven subtypes. It includes the enthesitis related arthritis (ERA) subtype which displays...
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Open AccessOverlap** genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
Genome wide association studies, replicated by numerous well powered validation studies, have revealed a large number of loci likely to play a role in susceptibility to many multifactorial diseases. It is now ...
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Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Eli Stahl and colleagues report results of a genome-wide association study meta-analysis and replication study for rheumatoid arthritis. Their work identifies several new risk loci and highlights genetic overl...
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Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
Soumya Raychaudhuri and colleagues demonstrate the utility of GRAIL, a software program used to prioritize results from genome-wide association studies for further replication, applied here to rheumatoid arthr...
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Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
Jane Worthington and colleagues report that three SNPs, located on chromosomes 10p15, 12q13 and 22q13, are associated with susceptibility to rheumatoid arthritis. These SNPs had previously been putatively asso...
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Rheumatoid arthritis association at 6q23
This is an issue edsumm for 32. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence shows that sea surface temperatures near the North Pole increased from roughly 18 degree...
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Open AccessFine map** of genes within the IDDM8region in rheumatoid arthritis
The IDDM8 region on chromosome 6q27, first identified as a susceptibility locus for type 1 diabetes, has previously been linked and associated with rheumatoid arthritis (RA). The region contains a number of poten...
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Open AccessLinkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure
The design of appropriate strategies to analyze and interpret linkage results for complex human diseases constitutes a challenge. Parameters such as power, definition of phenotype, and replicability have to be...
