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Article
Open AccessA living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity
High-grade serous ovarian carcinoma is characterised by TP53 mutation and extensive chromosome instability (CIN). Because our understanding of CIN mechanisms is based largely on analysing established cell lines, ...
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Article
Open AccessGlucocorticoid therapy regulates podocyte motility by inhibition of Rac1
Nephrotic syndrome (NS) occurs when the glomerular filtration barrier becomes excessively permeable leading to massive proteinuria. In childhood NS, immune system dysregulation has been implicated and increasi...
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Article
Open AccessA Galaxy-based bioinformatics pipeline for optimised, streamlined microsatellite development from Illumina next-generation sequencing data
Microsatellites are useful tools for ecologists and conservationist biologists, but are taxa-specific and traditionally expensive and time-consuming to develop. New methods using next-generation sequencing (NG...
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Article
Open AccessEvolution of candidate transcriptional regulatory motifs since the human-chimpanzee divergence
Despite the recent completion of the chimpanzee genome project, few functionally significant sequence differences between humans and chimpanzees have thus far been identified. Alteration in transcriptional reg...
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Article
Malaria is not responsible for the selection of TCR β-subunit variable gene haplotypes in The Gambia
Previous work has shown that a single haplotype of the T-cell antigen receptor β-subunit (TCRB) locus is predominant in African populations. This is likely to be due to selection pressure for gene(s) that pro...
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Article
Unique TCR β-subunit variable gene haplotypes in Africans
This study investigated polymorphisms of genes in two regions of the T-cell antigen receptor β-subunit (TCRB) locus, including BV9S2P, and BV6S7 in a 5′ linkage group, and BV8S3, BV24S1, BV25S1, BV18S1, BV2S1, B...
