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Open AccessHow to Define and Meet Blood Pressure Targets After Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) poses a significant challenge to healthcare providers, necessitating meticulous management of hemodynamic parameters to optimize patient outcomes. This article delves into the crit...
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Article
Venous-plexus-associated lymphoid hubs support meningeal humoral immunity
There is increasing interest in how immune cells in the meninges—the membranes that surround the brain and spinal cord—contribute to homeostasis and disease in the central nervous system1,2. The outer layer of th...
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Customised pre-operative cranioplasty to achieve maximal surgical resection of tumours with osseous involvement—a case series
Surgical resection with bony margins would be the treatment of choice for tumours with osseous involvement such as meningiomas and metastasis. By develo** and designing pre-operative customised 3D modelled i...
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Open AccessInterleukin-1 Receptor Antagonist as Therapy for Traumatic Brain Injury
Traumatic brain injury is a common type of acquired brain injury of varying severity carrying potentially deleterious consequences for the afflicted individuals, families, and society. Following the initial, t...
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Open AccessBrain tissue oxygen monitoring in traumatic brain injury—part II: isolated and combined insults in relation to outcome
The primary aim was to explore the concept of isolated and combined threshold-insults for brain tissue oxygenation (pbtO2) in relation to outcome in traumatic brain injury (TBI).
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Open AccessBrain tissue oxygen monitoring in traumatic brain injury: part I—To what extent does PbtO2 reflect global cerebral physiology?
The primary aim was to explore the association of global cerebral physiological variables including intracranial pressure (ICP), cerebrovascular reactivity (PRx), cerebral perfusion pressure (CPP), and deviati...
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Open AccessBenchmarking short-term postoperative mortality across neurosurgery units: is hospital administrative data good enough for risk-adjustment?
Surgical mortality indicators should be risk-adjusted when evaluating the performance of organisations. This study evaluated the performance of risk-adjustment models that used English hospital administrative ...
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Is dementia more likely following traumatic brain injury? A systematic review
The association between traumatic brain injury (TBI) and dementia is controversial, and of growing importance considering the ageing demography of TBI.
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Open AccessSystemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury
Neuroinflammation following traumatic brain injury (TBI) has been shown to be associated with secondary injury development; however, how systemic inflammatory mediators affect this is not fully understood. The...
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Open AccessCellular infiltration in traumatic brain injury
Traumatic brain injury leads to cellular damage which in turn results in the rapid release of damage-associated molecular patterns (DAMPs) that prompt resident cells to release cytokines and chemokines. These ...
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Article
Gut-educated IgA plasma cells defend the meningeal venous sinuses
The central nervous system has historically been viewed as an immune-privileged site, but recent data have shown that the meninges—the membranes that surround the brain and spinal cord—contain a diverse popula...
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Open AccessIndocyanine green fluorescence video angiography reduces vascular injury–related morbidity during micro-neurosurgical clip** of ruptured cerebral aneurysms: a retrospective observational study
Specific procedural complications in aneurysm surgery are broadly related to vascular territory compromise and brain/nerve retraction; vascular complications account for about half of this. Intraoperative indo...
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Open AccessRecent advances in traumatic brain injury
Traumatic brain injury (TBI) is the most common cause of death and disability in those aged under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income and middle-income countries ...
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Open AccessA case series of early and late cranioplasty—comparison of surgical outcomes
Cranioplasty is an increasingly common procedure performed in neurosurgical centres following a decompressive craniectomy (DC), however, timing of the procedure varies greatly.
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The patient’s perspective: follow-up Foix-Chavany-Marie syndrome secondary to bilateral traumatic operculum injury
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Open AccessFoix-Chavany-Marie syndrome secondary to bilateral traumatic operculum injury
This report describes a case of a 62-year-old man who developed Foix-Chavany-Marie syndrome subsequent to traumatic brain injury. The initial presentation of the syndrome was profound loss of voluntary control...
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Open AccessThe effect of succinate on brain NADH/NAD+ redox state and high energy phosphate metabolism in acute traumatic brain injury
A key pathophysiological process and therapeutic target in the critical early post-injury period of traumatic brain injury (TBI) is cell mitochondrial dysfunction; characterised by elevation of brain lactate/p...
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The relationship between neurosurgical instruments and disease transmission: Society of British Neurological Surgeons perspective
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Open AccessSpectrum of outcomes following traumatic brain injury—relationship between functional impairment and health-related quality of life
The outcome following traumatic brain injury (TBI) is heterogeneous and poorly defined and physical disability scales like the extended Glasgow Outcome Score (GOSE) while providing valuation information in ter...
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Open AccessA systematic review of cerebral microdialysis and outcomes in TBI: relationships to patient functional outcome, neurophysiologic measures, and tissue outcome
To perform a systematic review on commonly measured cerebral microdialysis (CMD) analytes and their association to: (A) patient functional outcome, (B) neurophysiologic measures, and (C) tissue outcome; after ...
