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Article
Anaesthesia for posterior cervical osteotomy
We have studied 22 consecutive cases of posterior cervical osteotomy done at the Toronto East General Hospital between October 1967 and November 1973.
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Article
Radiometric dating of sediments using fission tracks in conodonts
Conodonts are microfossils which are commonly found in marine rocks of Cambrian to Triassic age. Although their biological affinities are difficult to assess, conodonts are valuable stratigraphical indices for...
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Chapter and Conference Paper
Effects of Long-Term Administration of Sandostatin® (SMS 201–995) at Increasing Doses in 40 Acromegalic Patients. Results from the French Sandostatin Acromegaly Study Group
Several studies demonstrate the efficacy of short- and long-term Sandostatin® treatment in acromegaly administered subcutaneously at doses ranging from 150 to 300 µg up to 600 µg per day [1, 3, 5, 7–10]. A rhythm...
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Article
LONG TERM TREATMENT BY A LONG ACTING SOMATOSTATIN ANALOGUE (SMS 201–995) IN A 4 MONTHS BOY PRESENTING WITH PRIMARY PERMANENT HYPERINSULINISM
SMS 201-995 was used in a 4 month-old boy presenting hypoglycemic seizures with hyperinsulinism. The dose of SMS 201-995 was rapidly increased during the first week from 10 ug/kg/day to 100 ug/kg/day, and was ...
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Chapter and Conference Paper
Observations During a Clinical Trial of Sandostatin® in Acromegalic Patients
Ten acromegalic patients were studied over a period of 75 weeks. Four had had one or more attempted ablations of their pituitary adenoma, six were previously untreated or had been unsuccessfully treated with b...
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Chapter and Conference Paper
Long-Term Treatment of Acromegaly by Continuous Subcutaneous Infusion of the Long-Acting Somatostatin Analog Sandostatin® (SMS 201–995, Octreotide)
Recently the long-acting somatostatin analog Sandostatin® (SMS 201–995, Octreotide) was introduced for the therapy of acromegaly. On a two or three daily subcutaneous (s.c.) injection regimen plasma GH levels hav...
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Chapter and Conference Paper
Long-Term Efficacy of Sandostatin®(SMS 201–995, Octreotide) in 178 Acromegalic Patients. Results from the International Multicentre Acromegaly Study Group
Sandostatin® (SMS 201–995), a synthetic long-acting octapeptide, represents an efficacious alternative therapeutic candidate to available treatment modalities for acromegaly.
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Chapter and Conference Paper
Heart Size Reduction in Acromegalic Patientes Treated with the Long-Acting Somatostatin-Analogue SMS 201–995 (Somatostatin®)
Cardiomegaly by hypertrophy of the heart in acromegalic patients — prevalence 85% in our patients with acromegaly [1] — is often complicated by complex arrhythmias and gradual cardiac-insufficiency [1, 3, 8]. ...
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Article
Reduction in sella turcica volume
Ten patients with acromegaly were treated with the long-acting somatostatin analogue, Sandostatin (SMS 201-995, octreotide) for more than one year. Computerized tomography was performed before and on 4 differe...
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Article
Gallstones in acromegalic patients undergoing different treatment regimens
The frequency of gallstones during longterm treatment with the somatostatin analogue octreotide reported in different studies varies from 0% to 50%, the reason for this variation being unknown. Therefore, we e...
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Chapter and Conference Paper
Receptors and Their Modulation
The potential for hormonal intervention in cancer was identified as early as 1895, even before the concept of hormones was established. Indeed, we know that the first hormone was discovered only in 1902 (secre...
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Article
Clinical use of the long acting somatostatin analogue octreotide in pediatrics
Preliminary data of the use of the long-acting somatostatin analog octreotide (Sandostatin) in pediatrics are reported. In nesidioblastosis and other hyperinsulinemic conditions, timely treatment with octreoti...
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Article
Effects of octreotide on biliary lipid composition and occurrence of cholesterol crystals in patients with acromegaly
Treatment with the somatostatin analog octreotide is associated with increased gallstone formation. The mechanism of formation of these stones is unclear. The purpose of this study was to examine the effect of...
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Article
A prospective multicenter octreotide dose response study in the treatment of acromegaly
The somatostatin analog octreotide has proven to be an effective form of treatment for various hypersecretory states including acromegaly. This report describes the effects of escalating doses of octreotide on...
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Article
Consensus statement: Octreotide dose titration in secretory diarrhea
Octreotide is an effective therapeutic option in controlling secretory diarrhea of varied etiology. However, marked patient-to-patient differences in the antidiarrheal effects necessitate titration of octreoti...
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Article
Pyoderma gangrenosum with hepatopancreatic manifestations in a patient with rheumatoid arthritis
Pyoderma gangrenosum is a dermatological disease of unknown origin. We report the case of a 47-year-old woman with cutaneous lesions of pyoderma gangrenosum associated with hepaticopancreatic involvement. We f...
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Chapter and Conference Paper
Oxaceprol reduziert die Leukozyten-Adhärenz und -Extravasation und erhält die Perfusion des Gewebes nach Ischämie/Reperfusion (I/R) aufrecht
Akkumulation von Leukozyten, Beeinträchtigung der Perfusion sowie Steigerung der Permeabilität kennzeichnen den mikrovaskulären Ischämie/Reperfusions (I/R)-Schaden. Das Antiphlogistikum Oxaceprol ist zugelasse...
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Article
Solitary Hepatic Infantile Myofibromatosis in a Female Adolescent
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Chapter and Conference Paper
Langzeitkonservierung mit UW versus EC verbessert die Revaskularisierung des transplantierten Knochens
Zur Überbrückung langstreckiger Röhrenknochendefekte und zur Wiederherstellung der Gelenkfunktion nach Trauma wurde durch die allogene Transplantation vaskularisierter Knochen und Gelenke eine neue Behandlungs...
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Article
Implementation of the Microdialysis Method in the Hamster Dorsal Skinfold Chamber
The aim of this study was to implement the microdialysis method, a well-established technique for measuring the local concentration of neurotransmitters and metabolites in the brain, in the dorsal skinfold cha...
