27 Result(s)
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Article
Open AccessSingle-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions
Despite therapeutic advances, once a cancer has metastasized to the bone, it represents a highly morbid and lethal disease. One third of patients with advanced clear cell renal cell carcinoma (ccRCC) present w...
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Open AccessAcute ischemia induces spatially and transcriptionally distinct microglial subclusters
Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult and initiate immune inflammation, playing an important role in the cellular inj...
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Article
Open AccessPersonalized tumor combination therapy optimization using the single-cell transcriptome
The precise characterization of individual tumors and immune microenvironments using transcriptome sequencing has provided a great opportunity for successful personalized cancer treatment. However, the cancer ...
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Open AccessA meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes
Changes in cell-type composition of tissues are associated with a wide range of diseases and environmental risk factors and may be causally implicated in disease development and progression. However, these shi...
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Article
Deep learning tools for advancing drug discovery and development
A few decades ago, drug discovery and development were limited to a bunch of medicinal chemists working in a lab with enormous amount of testing, validations, and synthetic procedures, all contributing to cons...
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Open AccessA mutation-based gene set predicts survival benefit after immunotherapy across multiple cancers and reveals the immune response landscape
Immune checkpoint inhibitor (ICI) therapy has revolutionized the treatment of many cancers. However, the limited population that benefits from ICI therapy makes it necessary to screen predictive biomarkers for...
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Open AccessIntegrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19
Understanding the host genetic architecture and viral immunity contributes to the development of effective vaccines and therapeutics for controlling the COVID-19 pandemic. Alterations of immune responses in pe...
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Article
A stepwise mutagenesis approach using histidine and acidic amino acid to engineer highly pH-dependent protein switches
Antibody-based drugs can be highly toxic, because they target normal tissue as well as tumor tissue. The pH value of the extracellular microenvironments around tumor tissues is lower than that of normal tissue...
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Open AccessCorrection to: PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling
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Microbial composition and dynamic succession during the Daqu production process of Northern Jiang-flavored liquor in China
The microbial community structure and succession regularity of six key periods during high-temperature Daqu production were revealed using high-throughput sequencing to explore the factors affecting the flavor...
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Article
Open AccessPRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling
Aberrant changes in epigenetic mechanisms such as histone modifications play an important role in cancer progression. PRMT1 which triggers asymmetric dimethylation of histone H4 on arginine 3 (H4R3me2a) is upr...
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Article
Open AccessMicroglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation
Neuroinflammation and immune responses occurring minutes to hours after stroke are associated with brain injury after acute ischemic stroke (AIS). PPARγ coactivator-1α (PGC-1α), as a master coregulator of gene...
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Article
High-throughput sequencing of the microbial diversity of roasted-sesame-like flavored Daqu with different characteristics
The purpose of this experiment was to analyze the microbial community diversity in three Daqu samples displaying different characteristics in the same Daqu fermentation chamber. A high throughput sequencing te...
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Article
Open AccessMitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs
Mitochondrial DNA copy number (mtDNA-CN) has been associated with a variety of aging-related diseases, including all-cause mortality. However, the mechanism by which mtDNA-CN influences disease is not currentl...
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Article
A 17-bp InDel (rs668420586) within goat CHCHD7 gene located in growth-related QTL affecting body measurement traits
The Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7 (CHCHD7) gene was located in a growth-related major QTL that participated in the process of bone cells metabolism in animals by regulating mitochondrial...
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Exogenous phosphorus-solubilizing bacteria changed the rhizosphere microbial community indirectly
Phosphate-solubilizing bacteria (PSB) have been widely used as biological fertilizer. However, its impact on the local microbial community has less been known. In this study, a mixture of PSB was inoculated in...
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The Clinical Significance of Microsatellite Instability in Precision Treatment
The recent years have seen the high heterogeneity of colorectal cancer (CRC) receiving increasing attention and being revealed step by step. Microsatellite instability (MSI), characterized by the dysfunction o...
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Open AccesspTuneos: prioritizing tumor neoantigens from next-generation sequencing data
Cancer neoantigens are expressed only in cancer cells and presented on the tumor cell surface in complex with major histocompatibility complex (MHC) class I proteins for recognition by cytotoxic T cells. Accur...
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Article
Complete genome sequence of Rhodococcus sp. NJ-530, a DMSP-degrading actinobacterium isolated from Antarctic sea ice
Dimethylsulfide (DMS), a climatically important gas generated by dimethylsulfoniopropionate (DMSP) degradation, plays an important role in the global sulfur cycle and affects the global climate. Marine bacteri...
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De novo genome sequencing and secretome analysis of Tilletia indica inciting Karnal bunt of wheat provides pathogenesis-related genes
Tilletia indica is an internationally quarantined fungal pathogen causing Karnal bunt of wheat. The present study carried out that the whole genome of T. indica was sequenced and identified transposable elements,...
