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Article
Type I Interferon Signalling and Ischemic Stroke: Mechanisms and Therapeutic Potentials
Type I interferon (IFN-I) signalling is intricately involved in the pathogenesis of multiple infectious diseases, autoimmune diseases, and neurological diseases. Acute ischemic stroke provokes overactivation o...
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Article
Open AccessMicroglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model
Vitamin D deficiency is associated with worse clinical outcomes after ischemic stroke; nevertheless, the pathophysiological mechanisms remain largely unexplored. In this study, we characterized the molecular m...
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Chapter and Conference Paper
Prediction of Drug-Disease Relationship on Heterogeneous Networks Based on Graph Convolution
Drug-disease association prediction is essential in drug development and repositioning. At present, the proposed drug-disease association prediction models based on graph convolution usually learn the characte...
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Article
Open AccessMicroglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation
Neuroinflammation and immune responses occurring minutes to hours after stroke are associated with brain injury after acute ischemic stroke (AIS). PPARγ coactivator-1α (PGC-1α), as a master coregulator of gene...
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Article
An expedient method for regioselective methylation of catechol coumarins
An expedient and efficient method for selective methylation of catechol coumarins by working with different alkalis under appropriate reaction conditions is reported. Esculetins were selectively methylated at ...
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Article
Highly selective and efficient biotransformation of linarin to produce tilianin by naringinase
To develop a practical method to prepare tilianin by highly selective and efficient hydrolysis of the C-7 rhamnosyl group from linarin.
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Article
Open AccessFunctional and structural properties of a novel cellulosome-like multienzyme complex: efficient glycoside hydrolysis of water-insoluble 7-xylosyl-10-deacetylpaclitaxel
Cellulosome is a kind of multienzyme complex that displays high activity, selectivity and stability. Here, we report a novel, non-cellulolytic, cellulosome-like multienzyme complex that produced by the Cellulosim...
