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Article
Open AccessPersonalized tumor combination therapy optimization using the single-cell transcriptome
The precise characterization of individual tumors and immune microenvironments using transcriptome sequencing has provided a great opportunity for successful personalized cancer treatment. However, the cancer ...
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Article
Privacy-preserving integration of multiple institutional data for single-cell type identification with scPrivacy
The rapid accumulation of large-scale single-cell RNA-seq datasets from multiple institutions presents remarkable opportunities for automatically cell annotations through integrative analyses. However, the pri...
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Article
Open AccessDetection of ovarian cancer using plasma cell-free DNA methylomes
Ovarian cancer (OC) is a highly lethal gynecologic cancer, and it is hard to diagnose at an early stage. Clinically, there are no ovarian cancer-specific markers for early detection. Here, we demonstrate the u...
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Article
Open AccessA deep generative model for multi-view profiling of single-cell RNA-seq and ATAC-seq data
Here, we present a multi-modal deep generative model, the single-cell Multi-View Profiler (scMVP), which is designed for handling sequencing data that simultaneously measure gene expression and chromatin acces...
