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Article
Open AccessUnraveling temporal and spatial biomarkers of epithelial-mesenchymal transition in colorectal cancer: insights into the crucial role of immunosuppressive cells
The occurrence and progression of tumors can be established through a complex interplay among tumor cells undergoing epithelial-mesenchymal transition (EMT), invasive factors and immune cells. In this study, w...
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Article
Efficient tomato harvesting robot based on image processing and deep learning
Agricultural robots are rapidly becoming more advanced with the development of relevant technologies and in great demand to guarantee food supply. As such, they are slated to play an important role in precisio...
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Article
Dual ionically crosslinked chitosan–based injectable hydrogel as drug delivery system
Thermosensitive hydrogels based on chitosan play an important role in the field of tissue engineering and drug delivery system, with excellent properties such as biocompatible, biodegradable, and minimally inv...
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Article
Open AccessIntegrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19
Understanding the host genetic architecture and viral immunity contributes to the development of effective vaccines and therapeutics for controlling the COVID-19 pandemic. Alterations of immune responses in pe...
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Article
Open AccessSingle cell sequencing analysis identifies genetics-modulated ORMDL3+ cholangiocytes having higher metabolic effects on primary biliary cholangitis
Primary biliary cholangitis (PBC) is a classical autoimmune disease, which is highly influenced by genetic determinants. Many genome-wide association studies (GWAS) have reported that numerous genetic loci wer...
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Article
Construction and Functional Properties of Multifunctional Chitosan Hydrogel
Hydrogel is a kind of new functional polymer material with application value and economic benefit. It has wide application in biomedical field because of its good biocompatibility and hydrophilicity.In this wo...
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Chapter and Conference Paper
Insulator Segmentation Based on Community Detection and Hybrid Feature
Image segmentation is an important prerequisite for automatic detection of insulator’s surface defects. It is difficult to remove the interference by using traditional methods to segment insulator from aerial ...
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Article
Open AccessCase report of familial sudden cardiac death caused by a DSG2 p.F531C mutation as genetic background when carrying with heterozygous KCNE5 p.D92E/E93X mutation
Sudden cardiac death (SCD) induced by malignant ventricular tachycardia (MVT) among young adults with right ventricular cardiomyopathy/dysplasia (ARVC/D) is a devastating event. Parts of ARVC/D patients have a...
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Chapter
Functional Characterization of Non-coding RNAs Through Genomic Data Fusion
Acting as a class of regulators of gene expression, miRNAs play crucial roles in various biological processes, such as cell proliferation, differentiation, and apoptosis. Increasing evidence indicates that dys...
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Article
CDK6 mediates the effect of attenuation of miR-1 on provoking cardiomyocyte hypertrophy
MicroRNA-1 (miR-1) is approved involved in cardiac hypertrophy, but the underlying molecular mechanisms of miR-1 in cardiac hypertrophy are not well elucidated. The present study aimed to investigate the poten...
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Article
The caspase-8 shRNA-modified mesenchymal stem cells improve the function of infarcted heart
The beneficial effects of mesenchymal stem cells (MSCs) in cardiac cell therapy are greatly limited due to poor survival after transplantation into ischemic hearts. Here, we investigated whether caspase 8 smal...
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Article
An efficient method to enhance gene silencing by using precursor microRNA designed small hairpin RNAs
Gene silencing can be mediated by small interfering RNA (siRNA) and microRNA (miRNA). To investigate the potential application of using a precursor microRNA (pre-miRNA) backbone for gene silencing, we studied ...
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Article
Ethanol Enhances Glutamate Transmission by Retrograde Dopamine Signaling in a Postsynaptic Neuron/Synaptic Bouton Preparation From the Ventral Tegmental Area
It is well documented that somatodendritically released dopamine is important in the excitability and synaptic transmission of midbrain dopaminergic neurons. Recently we showed that in midbrain slices, acute e...
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Article
A simple and visualized method to screen for effective siRNAs by using green fluorescence protein (GFP) as a reporter
To screen for effective small interference RNA (siRNA), a simple and visualized method was developed using the green fluorescence protein (GFP) as a reporter. Candidate siRNAs targeting macrophage migration in...
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Article
Open AccessThrombin Receptor and Ventricular Arrhythmias after Acute Myocardial Infarction
The mechanism mediating the development of ventricular arrhythmia (VA) after acute myocardial Infarction (AMI) Is still uncertain. Thrombin receptor (TR) activation has been proven to be arrhythmogenic in many...
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Article
T1198C Polymorphism of the Angiotensinogen Gene and Antihypertensive Response to Angiotensin-Converting Enzyme Inhibitors
This study examined the association between T1198C polymorphism of the angiotensinogen (AGT) gene and the blood pressure response to ACE inhibitors in a Chinese hypertensive cohort. After a 2-week single-blind...
