3,851 Result(s)

Article

Selective PI3Kδ inhibitor TYM-3-98 suppresses AKT/mTOR/SREBP1-mediated lipogenesis and promotes ferroptosis in KRAS-mutant colorectal cancer

Colorectal cancer (CRC) is one of the most common tumors of the digestive system worldwide. KRAS mutations limit the use of anti-EGFR antibodies in combination with chemotherapy for the treatment of CRC. There...

Ya-nan Zheng, Si-yue Lou, Jun Lu, Fan-li Zheng, Yong-mei Tang… in Cell Death & Disease (2024)

Article

Correction: Sorcin regulate pyroptosis by interacting with NLRP3 inflammasomes to facilitate the progression of hepatocellular carcinoma

Zhenfen Li, Ziyue Yang, Yuanyuan Zhu, Chunmeng Fu, Ning Li… in Cell Death & Disease (2024)

Article

Macrophage migration inhibitory factor (MIF) suppresses mitophagy through disturbing the protein interaction of PINK1-Parkin in sepsis-associated acute kidney injury

Damage to renal tubular epithelial cells (RTECs) signaled the onset and progression of sepsis-associated acute kidney injury (SA-AKI). Recent research on mitochondria has revealed that mitophagy plays a crucia...

Tianlong Li, Jiachen Qu, Chang Hu, **g**g Pang, Yaoyao Qian… in Cell Death & Disease (2024)

Article

RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB/Bcl-2 signaling pathway

Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies and seriously threaten people’s health. Current therapies include bone marrow transplantation and several hypomethylating agents. However, ...

Li Liu, Chaoying Yang, Lin Zhu, Yanyan Wang, Fuxiang Zheng… in Cell Death & Disease (2024)

Article

Pig blastocyst-like structure models from embryonic stem cells

Pluripotent stem cells have the potential to generate embryo models that can recapitulate developmental processes in vitro. Large animals such as pigs may also benefit from stem-cell-based embryo models for im...

**zhu **ang, Hanning Wang, Bingbo Shi, Jiajun Li, Dong Liu, Kaipeng Wang… in Cell Discovery (2024)

Article

The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway

Metastasis is the major culprit of treatment failure in nasopharyngeal carcinoma (NPC). Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2), a core circadian gene, plays a crucial role in the develo...

Wenqing Zou, Yiming Lei, Cong Ding, Hongjun **ao, Shunxin Wang… in Cell Death & Disease (2024)

Article

Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis

The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process plays a crucial role in bone formation and homeostasis and is re...

Siyu Zhu, Wei Chen, Alasdair Masson, Yi-** Li in Cell Discovery (2024)

Article

A pan-KRAS degrader for the treatment of KRAS-mutant cancers

KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...

Jie Yang, Qiao-Li Wang, Guan-Nan Wang, Jia-Cong Ye, Zi-Qian Li… in Cell Discovery (2024)

Article

A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug

SARS-CoV-2 infection is initiated by Spike glycoprotein binding to the human angiotensin-converting enzyme 2 (ACE2) receptor via its receptor binding domain. Blocking this interaction has been proven to be an ...

Qianyun Liu, Yuchi Lu, Chenguang Cai, Yanyan Huang, Li Zhou… in Cell Death & Disease (2024)

Article

Promotion of stem cell-like phenotype of lung adenocarcinoma by FAM83A via stabilization of ErbB2

Lung cancer stands as the leading cause of mortality among all types of tumors, with over 40% of cases being lung adenocarcinoma (LUAD). Family with sequence similarity 83 member A (FAM83A) emerges as a notabl...

Ye Yuan, Liang Hao, **g-Shan Huang, Fu-Ying Zhao, Ying-Hua Ju… in Cell Death & Disease (2024)

Article

The adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects

ADGRF5 (GPR116) has been identified as a facilitator of breast cancer cell migration and metastasis, yet the underlying mechanisms remain largely elusive. Our current study reveals that the absence of ADGRF5 i...

Yalan Wu, Huixia Liu, Zhe Sun, Jieling Liu, Kai Li, Ronghui Fan… in Cell Death & Disease (2024)

Article

TRIM26 deficiency enhancing liver regeneration through macrophage polarization and β-catenin pathway activation

Liver regeneration is a complex process involving the crosstalk between parenchymal and non-parenchymal cells, especially macrophages. However, the underlying mechanisms remain incompletely understood. Here, w...

Tingting Li, Wei Zhong, Mengqi Li, Zile Shao, Gongye Zhang… in Cell Death & Disease (2024)

Article

TNIP3 protects against pathological cardiac hypertrophy by stabilizing STAT1

Pathological cardiac hypertrophy is one of the major risk factors of heart failure and other cardiovascular diseases. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown....

Hongjie Shi, Yongjie Yu, Dajun Li, Kun Zhu, Xu Cheng, Tengfei Ma… in Cell Death & Disease (2024)

Article

Structural and functional insights into the helicase protein E5 of Mpox virus

Mpox virus (MPXV) can cause mpox in humans. Due to its quick and wide spread in the past two years, mpox has turned into a significant public health concern. Helicase E5 is a multi-domain protein; its primer s...

Weizhen Zhang, Yusong Liu, Mengquan Yang, Jie Yang, Zhiwei Shao… in Cell Discovery (2024)

Article

Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15

Zhongyuan Zhang, You Zheng, Lu Xu, Yang Yue, Kexin Xu, Fei Li, Fei Xu in Cell Discovery (2024)

Article

Dexmedetomidine improves the circulatory dysfunction of the glymphatic system induced by sevoflurane through the PI3K/AKT/ΔFosB/AQP4 pathway in young mice

Multiple sevoflurane exposures may damage the develo** brain. The neuroprotective function of dexmedetomidine has been widely confirmed in animal experiments and human studies. However, the effect of dexmede...

Shuying Wang, **ao** Yu, Lili Cheng, Weishu Ren, Gehua Wen, Xue Wu… in Cell Death & Disease (2024)

Article

SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer

Endocrine resistance poses a significant clinical challenge for patients with hormone receptor-positive and human epithelial growth factor receptor 2-negative (HR + HER2−) breast cancer. Dysregulation of estro...

Kang Li, Dan Shu, Han Li, Ailin Lan, Wenjie Zhang, Zhaofu Tan… in Cell Death & Disease (2024)

Article

VHL suppresses UBE3B-mediated breast tumor growth and metastasis

Protein homeostasis is predominantly governed through post-translational modification (PTM). UBE3B, identified as an oncoprotein, exhibits elevated protein levels in breast cancer. However, the impact of PTM o...

Shuo Wang, Huiyan Li, **ong Liu, Tingting Yin, Tingru Li… in Cell Death & Disease (2024)

Article

RANKL/RANK signaling recruits Tregs via the CCL20–CCR6 pathway and promotes stemness and metastasis in colorectal cancer

TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily member 11 (TNFRSF11, RANKL) are overexpressed in many malignancies. However, the clinical importance of RANKL/RANK in colore...

**g Ouyang, Shuang Hu, Qingqing Zhu, Chenxin Li, Tingting Kang… in Cell Death & Disease (2024)

Article

LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide, necessitating the identification of novel therapeutic targets. Lysosome Associated Protein Transmembrane 4B (LAPTM4B) i...

Ruyu Yan, Dan Liu, Hongjuan Guo, Minxia Liu, Dong** Lv… in Cell Death & Disease (2024)