124 Result(s)
within
**jun He
Biomedicine, general
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Article
Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis
Angiogenesis plays a critical role in many pathological processes, including irreversible blindness in eye diseases such as retinopathy of prematurity. Endothelial mitochondria are dynamic organelles that unde...
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Article
zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function
CD80 is a transmembrane glycoprotein belonging to the B7 family, which has emerged as a crucial molecule in T cell modulation via the CD28 or CTLA4 axes. CD80-involved regulation of immune balance is a finely ...
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Article
Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis
γδ T cells play a crucial role in immune surveillance and serve as a bridge between innate and adaptive immunity. However, the metabolic requirements and regulation of γδ T-cell development and function remain...
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Article
Inflammation-related molecular signatures involved in the anticancer activities of brigatinib as well as the prognosis of EML4-ALK lung adenocarcinoma patient
Although ALK tyrosine kinase inhibitors (ALK-TKIs) have shown remarkable benefits in EML4-ALK positive NSCLC patients compared to conventional chemotherapy, the optimal sequence of ALK-TKIs treatment remains u...
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Article
Epitaxial quasi-2D/3D hybrid perovskite heterojunctions for photodetector with enhanced detectivity and stability
Although numerous metal halide perovskite materials have been investigated in the field of optoelectronic, the development of perovskite heterojunctions with exotic structures is still rare. Herein, we report ...
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Article
The roles of PD-L1 in the various stages of tumor metastasis
The interaction between tumor programmed death ligand 1 (PD-L1) and T-cell programmed cell death 1 (PD-1) has long been acknowledged as a mechanism for evading immune surveillance. Recent studies, however, hav...
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Article
Observation of robust anisotropy in WS2/BP heterostructures
Two-dimensional (2D) anisotropic materials have garnered significant attention in the realm of anisotropic optoelectronic devices due to their remarkable electrical, optical, thermal, and mechanical properties...
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Article
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway
Dry eye disease (DED) is a prevalent ocular disorder with a multifactorial etiology. The pre-angiogenic and pre-inflammatory milieu of the ocular surface plays a critical role in its pathogenesis. DZ2002 is a ...
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Article
Exploring the regulatory effect of stacked layers on moiré excitons in twisted WSe2/WSe2/WSe2 homotrilayer
Moiré superlattices in van der Waals structures have emerged as a powerful platform for studying the novel quantum properties of two-dimensional materials. The periodic moiré patterns generated by these struct...
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Article
Enhanced valley polarization in WSe2/YIG heterostructures via interfacial magnetic exchange effect
Exploiting the valley degrees of freedom as information carriers provides new opportunities for the development of valleytronics. Monolayer transition metal dichalcogenides (TMDs) with broken space-inversion s...
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Article
Kaempferide ameliorates cisplatin-induced nephrotoxicity via inhibiting oxidative stress and inducing autophagy
Acute kidney injury (AKI) caused by anti-tumor drugs, such as cisplatin, is a severe complication with no effective treatment currently, leading to the reduction or discontinuation of chemotherapy. Natural pro...
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Article
Pillar effect boosting the electrochemical stability of Prussian blue-polypyrrole for potassium ion batteries
Due to the high theoretical capacity and electrode potential, Prussian blue is regarded as promising cathode material for potassium ion batteries. However, inferior structural stability, poor electronic conduc...
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Article
Kelch-like proteins in the gastrointestinal tumors
Gastrointestinal tumors have become a worldwide health problem with high morbidity and poor clinical outcomes. Chemotherapy and surgery, the main treatment methods, are still far from meeting the treatment nee...
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Article
Solvent-stabilized few-layer violet phosphorus and its ultrafast nonlinear optics
Featured with high thermal decomposition temperature and layered structure, violet phosphorus (VP) offers an unparalleled stable allotrope of phosphorus to demonstrate the optoelectronic device and photonics e...
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Article
Open AccessNF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer
Adenoma-adenocarcinoma transition is a key feature of colorectal cancer (CRC) occurrence and is closely regulated by tumor-associated macrophages (TAMs) and CD8+ T cells. Here, we investigated the effect of the N...
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Article
Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells
Neddylation is a type of posttranslational protein modification that has been observed to be overactivated in various cancers. UBC12 is one of two key E2 enzymes in the neddylation pathway. Reports indicate th...
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Article
Open AccessDevelopment and safety of PI3K inhibitors in cancer
The phosphatidylinositol 3-kinase (PI3K) signalling pathway regulates cell survival, proliferation, migration, metabolism and other vital cellular life processes. In addition, activation of the PI3K signalling...
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Article
Effect of layered-coupling in twisted WSe2 moiré superlattices
Recently, the discovery of a variety of moiré-related properties in the twisted vertical stacking of two different monolayers has attracted considerable attention. The introduction of small twist angles in tra...
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Article
Fe-porphyrin: A redox-related biosensor of hydrogen molecule
Hydrogen molecule (H2) exhibits broad-spectrum but microenvironment-dependent biomedical effects in varied oxidation stress-related diseases, but its molecular mechanism is unclear and its targeting molecule is u...
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Article
Evidence for interlayer coupling and moiré excitons in twisted WS2/WS2 homostructure superlattices
The formation of moiré superlattices in twisted van der Waals (vdW) homostructures provides a versatile platform for designing the electronic band structure of two-dimensional (2D) materials. In graphene and t...
