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Article
Open AccessTargeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function
Cathepsin S (CTSS) is a cysteine protease that played diverse roles in immunity, tumor metastasis, aging and other pathological alterations. At the cellular level, increased CTSS levels have been associated wi...
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Article
Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation
Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contributes to other cellular processes, such as centrosome duplication. Small molecules targetin...
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Article
High-temperature polymer-based nanocomposites for high energy storage performance with robust cycling stability
High-power capacitors are highly demanded in advanced electronics and power systems, where rising concerns on the operating temperatures have evoked the attention on develo** highly reliable high-temperature...
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Article
Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells
Neddylation is a type of posttranslational protein modification that has been observed to be overactivated in various cancers. UBC12 is one of two key E2 enzymes in the neddylation pathway. Reports indicate th...
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Article
Lizhong Decoction Ameliorates Ulcerative Colitis in Mice via Regulation of Plasma and Urine Metabolic Profiling
To elucidate the mechanism of Lizhong Decoction (LZD) in treating dextran sodium sulfate (DSS)-induced colitis in mice based on metabonomics.
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Article
Network reliability evaluation of manufacturing systems by using a deep learning approach
A manufacturing system with reworking actions is constructed as a stochastic-flow manufacturing networks (SFMN) because components (arcs and nodes) are with multi-state capacity. Network reliability is a usefu...
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Article
Open AccessRibonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle
The balance among quiescence, differentiation, and self-renewal of skeletal muscle stem cells (MuSCs) is tightly regulated by their intrinsic and extrinsic properties from the niche. How the niche controls MuS...
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Article
Open AccessComparison of blood loss between tranexamic acid-soaked absorbable Gelfoam and topical retrograde injection via drainage catheter plus clam** in cervical laminoplasty surgery
To compare the safety and efficacy of tranexamic acid (TXA)-soaked absorbable Gelfoam and the retrograde injection of TXA through a drain with drain-clam** in degenerative cervical laminoplasty patients.
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Article
Lambda binding energies in the Skyrme-Hartree-Fock approach with various \(\Lambda N\) interactions
The Lambda binding energies \(B_\Lambda \) B Λ ...
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Chapter and Conference Paper
Design a Mobile Augmented Reality System to Facilitate Users’ Companionship Needs
With smartphones and wearable communication and information technologies (ICT) ubiquitous, mobile augmented reality systems (MARS) open up various opportunities for users to experience and interact with virtua...
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Article
Transjugular Intrahepatic Portosystemic Shunt Creation for Treatment of Gastric Varices: Systematic Literature Review and Meta-Analysis of Clinical Outcomes
To quantify the pooled clinical outcomes of stent-graft transjugular intrahepatic portosystemic shunt (TIPS) creation for the management of gastric varices (GVs) through systematic review of the literature and...
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Article
Open AccessAuthor Correction: Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessRod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease
To characterize rod- and cone-pathway function in the 5xFAD mouse model of Alzheimer’s disease (AD) using the full-field electroretinogram (ERG). Dark-adapted (DA; rod-pathway) and light-adapted (LA; cone-path...
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Article
Learning by supplying and competition threat
This study proposes a model of learning by supplying in an international outsourcing framework, where the supplier of a relationship-specific input can reverse engineer and become a competitor to its partner i...
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Article
Open AccessCytoskeletal disorganization underlies PABPN1-mediated myogenic disability
Muscle wasting and atrophy are regulated by multiple molecular processes, including mRNA processing. Reduced levels of the polyadenylation binding protein nucleus 1 (PABPN1), a multifactorial regulator of mRNA...
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Article
Item Cold-Start Recommendation with Personalized Feature Selection
The problem of recommending new items to users (often referred to as item cold-start recommendation) remains a challenge due to the absence of users’ past preferences for these items. Item features from side i...
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Article
Open AccessThe therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells
A1874 is a novel BRD4-degrading proteolysis targeting chimera (PROTAC). In primary colon cancer cells and established HCT116 cells, A1874 potently inhibited cell viability, proliferation, cell cycle progressio...
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Article
Microencapsulation of immunoglobulin Y: optimization with response surface morphology and controlled release during simulated gastrointestinal digestion
Immunoglobulin Y (IgY) is an effective orally administered antibody used to protect against various intestinal pathogens, but which cannot tolerate the acidic gastric environment. In this study, IgY was microe...
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Article
Evaluation of the physico-mechanical properties of activated-carbon enhanced recycled polyethylene/polypropylene 3D printing filament
In this study, recycled polymer feedstocks (high-density polyethylene, HDPE and polypropylene, PP) were added with different percentages of activated carbon (AC) made from coconut fiber waste – 0, 2, 4, 6, and...
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Article
Coenzyme Q10 Alleviates Chronic Nucleoside Reverse Transcriptase Inhibitor-Induced Premature Endothelial Senescence
Human immunodeficiency virus (HIV)-infected patients undergoing antiretroviral therapy are afforded an increased lifespan but also exhibit an elevated incidence of cardiovascular disease. HIV therapy uses a co...