22 Result(s)
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Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms
Smc5/6 is a member of the eukaryotic structural maintenance of chromosomes (SMC) family of complexes with important roles in genome maintenance and viral restriction. However, limited structural understanding ...
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Open AccessAuthor Correction: A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD
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Open AccessAuthor Correction: Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses
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Open AccessHost susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses
The bat coronaviruses (CoV) BANAL-20-52 and BANAL-20-236 are two newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) closely related coronaviruses (SC2r-CoV) and the genome of BANAL-2...
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Open AccessDecreased left heart flow in fetal lambs causes left heart hypoplasia and pro-fibrotic tissue remodeling
Low blood flow through the fetal left heart is often conjectured as an etiology for hypoplastic left heart syndrome (HLHS). To investigate if a decrease in left heart flow results in growth failure, we generat...
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Open AccessA broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD
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Open AccessSelection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages
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Publisher Correction: SARS-CoV-2 spike protein interacts with and activates TLR4
A Correction to this paper has been published: https://doi.org/10.1038/s41422-021-00501-0
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SARS-CoV-2 spike protein interacts with and activates TLR41
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Open AccessStructural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody
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Open AccessStructure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms
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Open AccessStructure-based development of human antibody cocktails against SARS-CoV-2
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Open AccessRational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection
Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic an...
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Article
Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2
Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease—a disease endemic especially in the Asia-Pacific region1. Scavenger receptor class B member 2 (SCARB2) is the major receptor of EV71, as wel...
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Open AccessA coumarin analogue NFA from endophytic Aspergillus fumigatus improves drought resistance in rice as an antioxidant
Drought and its resulting oxidative damage are the major yield limiting factors for crops in arid and semi-arid regions. Recent studies have found that endophytic fungi coexisting in plants can alleviate bioti...
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Cryo-EM structure of Type III-A CRISPR effector complex
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A choline binding polypeptide of LytA inhibits the growth of Streptococcus pneumoniae by binding to choline in the cell wall
Streptococcus pneumoniae is a pathogen that mainly affects children and elderly individuals. The numerous serotypes and increased resistance to antibiotics make the treatment of pneumococcal infections sometimes ...
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Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Japanese encephalitis virus (JEV), closely related to dengue, Zika, yellow fever and West Nile viruses, remains neglected and not well characterized1. JEV is the leading causative agent of encephalitis, and is re...
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Structure of human Aichi virus and implications for receptor binding
Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cause severe gastroenteritis and deaths in children below the age of five years, especially in developin...
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PTEN regulates RPA1 and protects DNA replication forks
Tumor suppressor PTEN regulates cellular activities and controls genome stability through multiple mechanisms. In this study, we report that PTEN is necessary for the protection of DNA replication forks agains...
