13 Result(s)

Article

Interleukin-35 -producing B cells rescues inflammatory bowel disease in a mouse model via STAT3 phosphorylation and intestinal microbiota modification

Interleukin-35 (IL-35)-producing B cells (IL-35⁺B cells) play an important role in diseases, and the expansion of IL-35⁺ immune cells have been observed in inflammatory bowel disease (IBD). However, how IL-35⁺B c...

Minxiang **e, Yuzhen Zhu, Yunjiao Zhou, Qiao Wang, Erli Gu… in Cell Death Discovery (2023)

Article

An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope

New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design. Here, we identified a re...

Zezhong Liu, Wei Xu, Zhenguo Chen, Wangjun Fu, Wuqiang Zhan, Yidan Gao… in Protein & Cell (2022)

Article

Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages

Lei Wang, Wangjun Fu, Linlin Bao, Zi**g Jia, Yuxia Zhang, Yunjiao Zhou… in Cell Research (2022)

Article

Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants

Omicron (B.1.1.529), the most heavily mutated SARS-CoV-2 variant so far, is highly resistant to neutralizing antibodies, raising concerns about the effectiveness of antibody therapies and vaccines^1,2. Here we exa...

Kang Wang, Zi**g Jia, Linilin Bao, Lei Wang, Lei Cao, Hang Chi, Yaling Hu… in Nature (2022)

Article

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback for global economy and health. SARS...

Qianqian Zhang, Rong **ang, Shanshan Huo… in Signal Transduction and Targeted Therapy (2021)

Article

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly become a global public health threat. The efficacy of several repurposed dr...

Fei Li, Ming Han, Pengfei Dai, Wei Xu, Juan He, **aoting Tao… in Nature Communications (2021)

Article

Clinical characteristics, laboratory outcome characteristics, comorbidities, and complications of related COVID-19 deceased: a systematic review and meta-analysis

At present, novel coronavirus disease 2019 (COVID-19) has become a serious global public health problem. The current meta-analysis aimed to find risk factors for the COVID-19-related death, hel** to enhance ...

Peishan Qiu, Yunjiao Zhou, Fan Wang… in Aging Clinical and Experimental Research (2020)