125 Result(s)
within
**-Tian Tang
Science, Humanities and Social Sciences, multidisciplinary
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Article
A paracrine requirement for hedgehog signalling in cancer
The hedgehog (Hh) signalling pathway acts in the develo** embryo as part of the network controlling cell proliferation and cell fate. It has also been implicated in a number of solid tumours, where it was th...
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Article
Dynamic performance test and estimation of reinforcement effect on a workshop after column-cut supported by joist
The reinforcement effect of a reconstruction scheme for a steel factory building was investigated using finite element method and dynamic performance test. The workshop concerned is a portal frame structure wi...
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Article
Open AccessGenome of the Chinese tree shrew
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as model...
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Article
Numerical modeling and simulation of temperature distribution uncertainty subject to ferromagnetic thermoseeds hyperthermia
In the process of ferromagnetic thermoseeds mediated magnetic induction hyperthermia, the temperature distribution in the tumor region is a key factor to determine the therapy effect. During the preoperative t...
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Article
Open AccessPGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner
This study was aimed to determine the role and regulation of progranulin (PGRN) in the pathogenesis of inflammatory bowel diseases (IBD). Dextran sulfate sodium (DSS)−, picrylsulfonic acid (TNBS)-induced, bone...
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Open AccessEvolutionary analysis of rubella viruses in mainland China during 2010–2012: endemic circulation of genotype 1E and introductions of genotype 2B
Rubella remains a significant burden in mainland China. In this report, 667 viruses collected in 24 of 31 provinces of mainland China during 2010–2012 were sequenced and analyzed, significantly extending previ...
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Article
Fruit intake decreases risk of incident type 2 diabetes: an updated meta-analysis
Association between fruit intake and risk of type 2 diabetes is inconsistent. In this study, we performed a meta-analysis of all prospective cohort studies to clarify the association between fruit intake and ...
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Open AccessGenetic Variability and Phylogenetic Analysis of Han Population from Guanzhong Region of China based on 21 non-CODIS STR Loci
In the present study, we presented the population genetic data and their forensic parameters of 21 non-CODIS autosomal STR loci in Chinese Guanzhong Han population. A total of 166 alleles were observed with co...
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Open AccessBiased random walk model for the prioritization of drug resistance associated proteins
Multi-drug resistance is the main cause of treatment failure in cancer patients. How to identify molecules underlying drug resistance from multi-omics data remains a great challenge. Here, we introduce a data ...
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Article
MiR-346 regulates CD4+CXCR5+ T cells in the pathogenesis of Graves’ disease
Follicular helper T (Tfh) cells are increasingly recognized as participants in various autoimmune diseases, including Graves’ disease. Although many transcription factors and cytokines are known to regulate Tf...
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Article
Open AccessDeletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice
The male’s ability to reproduce is completely dependent on Sertoli cells. However, the mechanisms governing the functional integrity of Sertoli cells have remained largely unexplored. Here, we demonstrate that...
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Article
Open AccessCis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer
Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susce...
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Open AccessGenetic discovery for oil production and quality in sesame
Oilseed crops are used to produce vegetable oil. Sesame (Sesamum indicum), an oilseed crop grown worldwide, has high oil content and a small diploid genome, but the genetic basis of oil production and quality is ...
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Article
Open AccessThe Long Noncoding RNA IFNG-AS1 Promotes T Helper Type 1 Cells Response in Patients with Hashimoto’s Thyroiditis
The long noncoding (lnc) RNA-Ifng-AS1 plays an essential role in the transcription of the gene encoding IFN-γ by Th1 cells and its human ortholog, IFNG-AS1, is expressed in human Th1 cells. However, IFNG-AS1 cont...
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Article
Open AccessBio-inspired Plasmonic Nanoarchitectured Hybrid System Towards Enhanced Far Red-to-Near Infrared Solar Photocatalysis
Solar conversion to fuels or to electricity in semiconductors using far red-to-near infrared (NIR) light, which accounts for about 40% of solar energy, is highly significant. One main challenge is the developm...
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Article
Open AccessBasic FGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons
Tendon injury during limb motion is common. Damaged tendons heal poorly and frequently undergo unpredictable ruptures or impaired motion due to insufficient innate healing capacity. By basic fibroblast growth ...
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Article
Open AccessCMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone
Elevated serum chemerin levels correlate with increased severity of polycystic ovary syndrome (PCOS). However, the role of CMKLR1 signaling in ovarian biology under conditions of excess DHT remains unclear. In...
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Article
Open AccessMNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways
The MAP kinase-interacting kinases (MNK1 and MNK2) are non-essential enzymes which are activated by MAP kinases. They are implicated in controlling protein synthesis. Here we show that mice in which the expres...
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Open AccessEnhanced Flexible Tubular Microelectrode with Conducting Polymer for Multi-Functional Implantable Tissue-Machine Interface
Implantable biomedical microdevices enable the restoration of body function and improvement of health condition. As the interface between artificial machines and natural tissue, various kinds of microelectrode...
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Article
Open AccessA Schisandra-Derived Compound Schizandronic Acid Inhibits Entry of Pan-HCV Genotypes into Human Hepatocytes
Despite recent progress in the development of hepatitis C virus (HCV) inhibitors, cost-effective antiviral drugs, especially among the patients receiving liver transplantations, are still awaited. Schisandra i...
