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Article
IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection
The retinoic acid-inducible gene I (RIG-I) receptor senses cytoplasmic viral RNA and activates type I interferons (IFN-I) and downstream antiviral immune responses. How RIG-I binds to viral RNA and how its act...
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Article
Overexpression of ADAMTS-7 leads to accelerated initiation and progression of collagen-induced arthritis in mice
The aim of the present study is to determine whether ADAMTS-7 contributes to the onset and severity of joint inflammation in the pathogenesis of inflammatory arthritis. ADAMTS-7 was found to be elevated in the...
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Article
Open AccessPGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner
This study was aimed to determine the role and regulation of progranulin (PGRN) in the pathogenesis of inflammatory bowel diseases (IBD). Dextran sulfate sodium (DSS)−, picrylsulfonic acid (TNBS)-induced, bone...
