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  1. Article

    Open Access

    Integrative analysis of chromatin accessibility and transcriptome landscapes in the induction of peritoneal fibrosis by high glucose

    Peritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis.

    Qiong Song, Pengbo Wang, Huan Wang, Mei**g Pan in Journal of Translational Medicine (2024)

  2. No Access

    Article

    Downregulation of TMEM220 promotes tumor progression in Hepatocellular Carcinoma

    During the process of long-term carcinogenesis, cells accumulate many mutations. Deregulated genes expression causes profound changes in cell proliferation, which is one of the hallmarks of HCC. A comprehensiv...

    Ting Li, Lei Guan, Guangbo Tang, Bing He, Lili Huang, Juan Wang in Cancer Gene Therapy (2022)

  3. Article

    Open Access

    MEIS2C and MEIS2D promote tumor progression via Wnt/β-catenin and hippo/YAP signaling in hepatocellular carcinoma

    MEIS2 has been identified as one of the key transcription factors in the gene regulatory network in the development and pathogenesis of human cancers. Our study aims to identify the regulatory mechanisms of ME...

    Lei Guan, Ting Li, Nan** Ai, Wei Wang in Journal of Experimental & Clinical Cancer … (2019)

  4. Article

    Open Access

    Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer

    Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we analysis structural variations (SVs) and mutational signatures via whole-genome sequenci...

    Rui **ng, Yong Zhou, Jun Yu, Yingyan Yu, Yongzhan Nie, Wen Luo in Nature Communications (2019)

  5. No Access

    Article

    Forkhead box C1 promotes colorectal cancer metastasis through transactivating ITGA7 and FGFR4 expression

    Metastatic colorectal cancer (CRC) is one of the most common causes of cancer death worldwide; however, the molecular mechanism underlying CRC metastasis remains unknown. Using an integrated approach, we ident...

    Jian Liu, Zhe Zhang, **aowei Li, Jie Chen, Guodong Wang, Zuhong Tian in Oncogene (2018)

  6. Article

    Open Access

    Biased random walk model for the prioritization of drug resistance associated proteins

    Multi-drug resistance is the main cause of treatment failure in cancer patients. How to identify molecules underlying drug resistance from multi-omics data remains a great challenge. Here, we introduce a data ...

    Hao Guo, Jiaqiang Dong, Sijun Hu, **qiang Cai, Guangbo Tang in Scientific Reports (2015)