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1,908 Result(s)
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Article
Open AccessRadiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells
Immunosuppression by the tumor microenvironment is a pivotal factor contributing to tumor progression and immunotherapy resistance. Priming the tumor immune microenvironment (TIME) has emerged as a promising s...
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Structural and electronic properties of clathrate-like hydride: MH6 and MH9 (M = Sc, Y, La)
The addition of central metal atoms to hydrogen clathrate structures is thought to provide a certain amount of “internal chemical pressure” to offset some of the external physical pressure required for compoun...
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Open AccessComparative Analysis of Seven Endogenous Hormones in a Novel Dual-axillary Bud Mutant Genotype of Sugarcane
The sugarcane genotype YZ 07-86 is a distinct natural mutant with dual-axillary buds. Exploitation of this valuable trait in sugarcane breeding requires an understanding of the physiological mechanism of dual-...
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Dahuang Zhechong Pill Alleviates Liver Fibrosis Progression by Regulating p38 MAPK/NF-κ B/TGF-β1 Pathway
To explore the effect and mechanism of Dahuang Zhechong Pill (DHZCP) on liver fibrosis.
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Open AccessSusceptibility gene identification and risk evaluation model construction by transcriptome-wide association analysis for salt sensitivity of blood pressure
Salt sensitivity of blood pressure (SSBP) is an intermediate phenotype of hypertension and is a predictor of long-term cardiovascular events and death. However, the genetic structures of SSBP are uncertain, an...
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Preparation of UiO-66-NH2@cellulose nanofiber composite film and its adsorption performance study towards Cd(II)
A novel heavy metal ion adsorbent, UiO-66-NH2@cellulose nanofiber membrane, was successfully synthesized using cellulose and polyvinyl alcohol as substrates and UiO-66-NH2 as the loading material. The adsorption ...
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Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice
Injuries to the brain result in tunable cell responses paired with stimulus properties, suggesting the existence of intrinsic processes that encode and transmit injury information; however, the molecular mecha...
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ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis
Suppression of neuroinflammation using small molecule compounds targeting the key pathways in microglial inflammation has attracted great interest. Recently, increasing attention has been gained to the role of...
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Enhancing biomass and ecological sustainability in rice–fish cocrop** systems through the induction of functional microbiota with compound biogenic bait
Compound biological bait can replace commercial bait to ensure fish growth.
The compound biogenic bait can effectively impro...
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Article
A widely used nonionic surfactant with desired functional groups as aqueous electrolyte additives for stabilizing Zn anode
Aqueous Zn-ion batteries (AZIBs) have emerged as potential candidates for Li-ion batteries due to their intrinsic safety and high capacity. However, metallic Zn anodes encounter dendrite growth and water-induc...
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TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response
Abnormal expression of T-lymphokine-activated killer cell-originated protein kinase (TOPK) was reported to be closely related to the resistance of prostate cancer to radiotherapy and to targeted drug resistanc...
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Article
Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam
Two new sesterterpenoids, atractylodes japonica terpenoid acid I (1) and atractylodes japonica terpenoid aldehyde I (2), were isolated from the rhizomes of Atractylodes japonica Koidz. ex Kitam together with ten ...
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Open AccessHBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis
The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could t...
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Article
Design and synthesis of polyoxovanadate-based framework for efficient dye degradation
A new polyoxovanadate-based framework material [Cu(en)2]4V18O42(H2O)·6H2O (1) was designed and synthesized by hydrothermal reaction of NaVO3, Cu(NO3)2·6H2O and 1, 2-diaminoethane (en) via carefully adjusting the ...
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Article
Energy band modulation of N-doped rutile/anatase TiO2 photoanode promoting charge separation toward prominent photoelectrochemical performance
To solve the problem of high photogenerated carrier recombination rate and low photoelectric conversion efficiency of TiO2-based materials, a simple N-doped anatase/rutile TiO2 heterophase nanorod film was design...
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Open AccessNIR-II emissive anionic copper nanoclusters with intrinsic photoredox activity in single-electron transfer
Ultrasmall copper nanoclusters have recently emerged as promising photocatalysts for organic synthesis, owing to their exceptional light absorption ability and large surface areas for efficient interactions wi...
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Reference Intervals of Serum Iodine Concentration in Chinese Pregnant Women
The study aims to establish trimester-specific reference ranges for serum iodine (SI) in Chinese pregnant women and explore its associations with maternal and infantile thyroid function. Apparently healthy pre...
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Open AccessAn efficient molecular genetic testing strategy for incontinentia pigmenti based on single-tube long fragment read sequencing
Incontinentia pigmenti (IP) is a rare X-linked dominant neuroectodermal dysplasia that primarily affects females. The only known causative gene is IKBKG, and the most common genetic cause is the recurrent IKBKG△4...
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A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the epidermal growth factor precursor homologous domain A (EGF-A) of low-density lipoprotein receptor (LDLR) in the liver and triggers the degrada...
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Open AccessPrevalence and risk factors for dementia and mild cognitive impairment among older people in Southeast China: a community-based study
With the aging population, the number of individuals with dementia in China is increasing rapidly. This community-based study aimed to investigate the prevalence and risk factors for dementia and mild cognitiv...