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Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam

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Abstract

Two new sesterterpenoids, atractylodes japonica terpenoid acid I (1) and atractylodes japonica terpenoid aldehyde I (2), were isolated from the rhizomes of Atractylodes japonica Koidz. ex Kitam together with ten known compounds (3–12). Their structures were elucidated on the basis of comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS and IR). In addition, all of these isolated compounds were evaluated for their cytotoxic activities against human gastric cancer cell MGC-803 and human hepatocellular cancer cell HepG-2. Most of them exhibited moderate to weak inhibitory effects with IC50 values in the range of 25.15–88.85 μM except for 9–12.

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Acknowledgements

Thanks for the support of New Drug Research Foundation of Heilongjiang University of Chinese Medicine (2018xy02) and Heilongjiang Touyan Innovation Team Program.

Funding

This work was financially sponsored partly by grants from Natural Science Foundation of Heilongjiang Province of China (grant number LH2019H048), China Postdoctoral Science Foundation funded project (grant number 2013M530164 and 2014T70374), New Drug Research Foundation of Heilongjiang University of Chinese Medicine (grant number 2018xy02), Heilongjiang Touyan Innovation Team Program (grant number 2019–5-39).

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Authors and Affiliations

  1. Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, (Heilongjiang University of Chinese Medicine), 150040, Harbin, People’s Republic of China

    Yuan-Yuan Zhou, Zhao Sun, Yan Liu, Hui-Rui Gao, Ning-Yu Liu, Bing-You Yang & Hai-Xue Kuang

  2. Institute of Nature and Ecology, Heilongjiang Academy of Sciences, 150040, Harbin, People’s Republic of China

    Zhen-**ng Fang

  3. Academic research department, Heilongjiang University of Traditional Chinese Medicine, 150040, Harbin, People’s Republic of China

    **ao-Juan Zhang

Authors
  1. Yuan-Yuan Zhou
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  2. Zhao Sun
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  3. Yan Liu
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  4. Zhen-**ng Fang
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  5. Hui-Rui Gao
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  6. Ning-Yu Liu
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  7. **ao-Juan Zhang
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  8. Bing-You Yang
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  9. Hai-Xue Kuang
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Contributions

Yuan-Yuan Zhou: Conceptualization, Methodology, Writing-Review & Editing. Zhao Sun: Data Curation, Visualization, Writing-Original Draft. Yan Liu: Investigation, Validation, Resources. Zhen-**ng Fang: Investigation, Validation. Hui-Rui Gao: Data Curation, Visualization. Ning-Yu Liu: Data Curation, Visualization. **ao-Juan Zhang: Formal analysis, Writing—Review & Editing. Bing-You Yang: Supervision, Project administration. Hai-Xue Kuang: Supervision, Project administration.

Corresponding authors

Correspondence to Bing-You Yang or Hai-Xue Kuang.

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Conflict of interest

The method of extraction and separation of the new compounds described in the paper has already been patented by us under Patent No. CN113214214A. And there are no conflicts of interest with the authors.

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Zhou, YY., Sun, Z., Liu, Y. et al. Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam. J Nat Med 78, 702–708 (2024). https://doi.org/10.1007/s11418-024-01793-3

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  • DOI: https://doi.org/10.1007/s11418-024-01793-3

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