24 Result(s)
within
Chapter
Li**g Du
English
Biochemistry, general
Human Genetics
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Chapter
Telomerase Mutations and Premature Ageing in Humans
Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome which gets its name from the classic diagnostic triad of abnormal skin pigmentation, nail dystrophy, and leukoplakia. Most DC patien...
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Chapter
Hybrid Peptide-Polyketide Natural Products: Biosynthesis and Prospects Towards Engineering Novel Molecules
Polyketides and nonribosomal peptides are two groups of secondary metabolites found in many microorganisms and plants. Biosynthesis and genetic engineering of polyketide and nonribosomal peptide natural produc...
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Chapter
Sodium Induced Regulation of Angiotensin Receptor 1A And 1B in Rat Kidney
Two AT1 receptor subtypes, AT1A and AT1B, have been cloned and sequenced in the rat.15 Although AT1A and AT1B share a high degree (96%) of amino acid homology,3, 5 they may be functionally different. In studies o...
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Chapter and Conference Paper
Polymorphism of HLA-DRB3 and DRB4 Genes Detected by RFLPs
All the characterized human HLA class II genes are encoded within the major histocompatibility complex (MHC) on the short arm of chromosome six. Among the five subregions of the class II region, HLA-DR is uniq...
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Chapter and Conference Paper
The Generation of Class II Polymorphism by Recombination
One of the most striking features of the HLA gene products is their high degree of polymorphism. The HLA class II polymorphism varies from locus to locus, e.g. at present there are 18 serological defined antig...
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Chapter and Conference Paper
RFLP Standardization Report for DR Alpha/KpnI
Four bands were identified by the RFLP analysis in the DR alpha/KPN system as shown in Table 1 and in Figure 1. RFLP patterns of the core cell lines are shown in Table 2.
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Chapter and Conference Paper
RFLP Standardization Report for DP Alpha/KpnI
Six bands were identified by the RFLP analysis in the DP alpha/KPN system as shown in Table 1 and in Figure 1. RFLP patterns of the core cell lines are shown in Table 2.
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Chapter and Conference Paper
DR3 (DRw17, DRw18): 2-D Gel Patterns
Six DR3 cell lines were included in the Workshop study (Table 1). Two-dimensional (2-D) gel patterns for both α chains and β chains were obtained using the panel of core monomorphic and selected polymorphic mo...
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Chapter and Conference Paper
Unusual DR-DQ Haplotypes
The linkage disequilibrium existing between HLA-DR and DQ antigens is so strong that associations that do not follow the pattern appear as exceptions. In Caucasoids, the associations are well known: DQw1 is li...
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Chapter and Conference Paper
Evolutions of the Immune System
Determining the relative importance of the elements of the immune sytem is a major task to which comparative studies may help first in pointing to key elements and second in suggesting their phylogenetic origi...
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Chapter and Conference Paper
Antigen Society #26 Report (DR3, DR7, DQw2): Part 1
There were 1,019 cells analyzed in the Antigen Society (795 Caucasians, 202 Negroes, 22 Orientals); 1,011 were tested both on Core serology and Antigen Society reagents. The total number of sera and monoclonal...
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Chapter and Conference Paper
DQw2: 2-D Gel Patterns
The pH gradient used in this study was not optimal for the two-dimensional (2-D) gel analysis of the DQβ chains from DQw2 cell lines. Therefore, only the most acidic, highly glycosylated form of this extremely...
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Chapter and Conference Paper
DQw4 (Wa): 2-D Gel Patterns
DQw4 (Wa) is a class II specificity defined in the 10th Workshop as a fourth allele at the DQ locus. It is revealed serologically with the mouse monoclonal antibody Hu-46, which reacts with some DR4 and DRw8 h...
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Chapter and Conference Paper
Antigen Society #2 Report (A25, A26, AW34, AW43 and AW66)
The HLA antigens A25, A26, AW34, AW43, and AW66 form a strongly cross-reacting group as most sera to these antigens react with two or more of these specificities. Monospecific sera against some of these specif...
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Chapter and Conference Paper
Antigen Society #12 Report (Bw54, Bw55, Bw56 and Bw42)
The antigen Bw54 was officially designated as a split of Bw22 at the Seventh International Histocompatibility Workshop. This antigen was primarily defined in the Japanese population by several laboratories ind...
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Chapter and Conference Paper
Antigen Society #18 Report (Cw4 and Cw6)
HLA-Cw4 (formerly T4, RH315) and HLA-Cw6 (formerly T7) obtained the formal HLA designation after the Sixth and Seventh International Histocompatibility Workshops respectively (1,2). Since then, it has been obs...
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Chapter and Conference Paper
T Cell Differentiation in Lower Vertebrates
With all the recent advances in the study of T cell differentiation in mice, it is reasonable to question whether anything can be fetched from the examination of this problem in lower vertebrates. One obvious ...
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Chapter and Conference Paper
Southern Blot Analysis of Rheumatoid Arthritis
The methods and materials used in the Southern blot analysis of rheumatoid arthritis (RA) study were identical to the conditions used in the core and family study sections of the Tenth Workshop (10WS) Southern...
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Chapter and Conference Paper
DRw6 (DRw13, DRw14): 2-D Gel Patterns
DRw6 (DRw13,DRw14) haplotypes were previously considered to be the most enigmatic group of HLA class II specificities. This was largely due to the lack of monospecific anti-DRw6 alloantisera. Through the combi...
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Chapter and Conference Paper
Antigen Society #25 Report DRw6, DRw13, DRw14)
Since the Ninth International Histocompatibility Workshop 1984, two splits of HLA-DRw6 have been recognized: DRw13 and DRw14(1). Both specificities were included in DRw52 and highly associated with DQw1. At th...
