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Article
Open AccessThe Clinical Efficacy of Fibrinogen Concentrate in Massive Obstetric Haemorrhage with Hypofibrinogenaemia
Massive obstetric haemorrhage remains a major cause of maternal death attributable to hypofibrinogenaemia. Transfusion of large volumes of fresh frozen plasma (FFP) is required to normalise fibrinogen levels. ...
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Article
Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study
It has been suggested that micronutrients such as alpha-tocopherol, retinol, lutein, cryptoxanthin, lycopene, and alpha- and beta-carotene may help in the prevention of cervical cancer. Our aim was to investig...
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Article
Subsequent risks for cervical precancer and cancer in women with low-grade squamous intraepithelial lesions unconfirmed by colposcopy-directed biopsy: results from a multicenter, prospective, cohort study
To investigate the natural course of low-grade squamous intraepithelial lesions (LSILs) that cannot be histologically confirmed by colposcopy-directed biopsy.
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Article
Five-year results of cyclic semi-high dose neoadjuvant chemotherapy supported by autologous peripheral blood stem-cell transplantation in patients with advanced ovarian cancer
To achieve anti-ovarian tumor responses similar to those obtained with high-dose chemotherapy but with milder side effects, we developed a treatment protocol in which semi-high dose multi-cycle neoadjuvant che...
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Article
Two newly identified HLA-DRB1 alleles: DRB1 * 1322 and DRB1 * 1327
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Chapter
Two-Dimensional IEF Analysis of DR, DQ, and DP Molecules from DRW8-Carrying Haplotypes
HLA-DR, DQ, and DP molecules were isolated from eight HLA-DRw8 homozygous B-cell lines using the monoclonal antibodies (MAb) submitted to the 10th International Histocompatibility Workshop. These molecules wer...
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Chapter
HLA Antigens in Japanese Patients with Childhood-Onset Myasthenia Gravis
Myasthenia gravis (MG) is an autoimmune disorder that affects neuromuscular junctions. In Japanese, the age of onset of MG shows a bimodal distribution, with the first and highest peak before the age of two an...
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Chapter
Three Subtypes of DRw52 Molecules Among DR3, DR5, and DRw6 Haplotypes
In the HLA-DR subregion, two allelic series of DR molecules, DR1-DRw14 and DRw52–DRw53, have been recognized. DRw52 is supertypic to DR and is found in association with DR3, DR5, DRw6, and DRw8. We recently pr...
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Chapter and Conference Paper
DQw4 (Wa): 2-D Gel Patterns
DQw4 (Wa) is a class II specificity defined in the 10th Workshop as a fourth allele at the DQ locus. It is revealed serologically with the mouse monoclonal antibody Hu-46, which reacts with some DR4 and DRw8 h...
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Chapter
DR2 and DQw1 Molecules in Narcolepsy
Narcolepsy is a clinical disease entity characterized by excessive daytime sleepiness and cataplexy. The cause and genetic basis for the disease has been unknown until 1984, when an extraordinary association b...
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Chapter and Conference Paper
DRw8: 2-D Gel Patterns
Five DRw8,Dw8 cell lines (Table 1) that have been previously characterized serologically and cellularly (4,5) were analyzed in this study. The biochemical analysis of their class II antigens was performed usin...
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Article
Taq I-generated HLA-DQ αpolymorphism in Japanese patients with narcolepsy
Taq I-generated HLA-DQαrestriction fragment length polymorphism was examined in Japanese patients with narcolepsy. All patients were DR2 positive and shared a 6.0 kb fragment, although this fragment was found onl...
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Article
Defective expression of HLA class I antigens: A case of the bare lymphocyte without immunodeficiency
A case of the bare lymphocyte without apparent immunodeficiency was observed in a 33-year-old woman who had no history of severe infections but suffered from sino-bronchial disease. No HLA-A and -B antigens (c...
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Article
Identification of the MT3 molecule using two-dimensional gel electrophoresis and alloantisera
The MT3 antigen is defined serologically as a DR supertypic specificity and is strongly associated with DR4, DR7, and DRw9. To determine whether the MT3 molecule is distinct from the DR molecule, DR4 and MT3 a...