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  1. Article

    Open Access

    Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity?

    There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied. A geographically specific association with HLA-B7 &...

    Donald J Lehmann, Martin CNM Barnardo, Susan Fuggle… in Journal of Neuroinflammation (2006)

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    Chapter and Conference Paper

    DR3 (DRw17, DRw18): 2-D Gel Patterns

    Six DR3 cell lines were included in the Workshop study (Table 1). Two-dimensional (2-D) gel patterns for both α chains and β chains were obtained using the panel of core monomorphic and selected polymorphic mo...

    Susan Fuggle, Christine Carter, Steven Sacks, Susan Radka… in Immunobiology of HLA (1989)

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    Chapter and Conference Paper

    DQw2: 2-D Gel Patterns

    The pH gradient used in this study was not optimal for the two-dimensional (2-D) gel analysis of the DQβ chains from DQw2 cell lines. Therefore, only the most acidic, highly glycosylated form of this extremely...

    Susan Radka, Susan Fuggle, Maria Christina Mazzilli… in Immunobiology of HLA (1989)

  4. No Access

    Chapter and Conference Paper

    DQw4 (Wa): 2-D Gel Patterns

    DQw4 (Wa) is a class II specificity defined in the 10th Workshop as a fourth allele at the DQ locus. It is revealed serologically with the mouse monoclonal antibody Hu-46, which reacts with some DR4 and DRw8 h...

    Lydia Kulova, Hiroo Maeda, Ronald Bontrop, Nigel Rust, Susan Fuggle… in Immunobiology of HLA (1989)

  5. No Access

    Chapter and Conference Paper

    DR2 (DRw15, 16): 2-D Gel Patterns

    The results of the 9th Workshop identified two serologic splits within the DR2 haplotype (long and short). Heterogeneity was also defined by cellular ty**; three forms were identified and described as Dw2 (c...

    Nigel Rust, Christine Carter, Susan Fuggle, Steven Sacks… in Immunobiology of HLA (1989)

  6. No Access

    Chapter and Conference Paper

    DQw1 (DQw5, DQw6): 2-D Gel Patterns

    The HLA-DQw1 specificity was the first supertypic specificity recognized and was described at the 7th Workshop(1). Structural differences have been demonstrated between DQ molecules associated with DR1, DR2, a...

    Cecile Kaplan, Marie-Christine Morel, Pierre Hermans, Jean Tkaczuk… in Immunobiology of HLA (1989)

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    Chapter and Conference Paper

    DRw52: 2-D Gel Patterns

    The HLA-DRw52 specificity comprises a group of supertypic determinants, normally expressed on DR3, DR5, DRw6, and DRw8 positive cells, which can be detected by means of alloantisera (1), monoclonal antibodies ...

    Ronald Bontrop, Manfred Ballas, Alejandro Madrigal, Pierre Hermans… in Immunobiology of HLA (1989)

  8. No Access

    Chapter and Conference Paper

    DQw3 (DQw7, DQw8, DQw9): 2-D Gel Patterns

    DQw3 polymorphism has been described previously at the serologic, biochemical, and genomic level (1–8). In the present study, HLA class II α and β chain polymorphism was investigated by two-dimensional (2-D) g...

    Christina Mazzilli, Enrico Gandini, Jerry Lanchbury… in Immunobiology of HLA (1989)