23 Result(s)
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Chapter
**ng Long
Animal Anatomy / Morphology / Histology
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Origin of new genes: evidence from experimental and computational analyses
Exon shuffling is an essential molecular mechanism for the formation of new genes. Many cases of exon shuffling have been reported in vertebrate genes. These discoveries revealed the importance of exon shuffli...
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Homo-oligomeric opioid analogues and incorporation of 4-trans-aminomethylcyclohexanecarboxylic acid (Amcca)
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Bicyclic Peptide Inhibitors of an Epithelial Cell-Derived Transmembrane Protease, Matriptase
Matriptase is a recently identified type II transmembrane protease that is found on the surface of epithelial cells [1,2]. It is overexpressed in most cancer cells, including human breast cancer cells. It is a...
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Antimicrobial and Chemotactic Activities of ω-Conotoxin Cyclic Analogues
The family of ω-conotoxins isolated from paralytic venomous of Conus snails has been known to be an antagonist of presynaptic N-type calcium ion channels. They share certain similarities to the newly discovered f...
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Design of Cyclic α-Defensin Dimers as Channel Forming BuildingBlocks
Defensins exhibit antimicrobial activity toward bacteria, yeast, fungi and enveloped viruses. Studies indicate that the microbe killing activity is related to their pore forming and membrane permeabilizing pro...
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Functional and Structural Comparisons of Linear and Dendritic Arrays of Polypeptides
Bioactive biopolymers with repeating sequences are often found in nature. Polypeptides usually contain an array of linear repeats, whereas both linear and dendritic repeats are found in polysaccharides. To det...
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Regulation of Immune Responses by Inhibitory Receptors
Biological responses, including those occurring during immune responses, must be controlled by signals that turn them on, as well as signals that turn them off. In addition, fine-tuning can be achieved through...
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Molecular Phylogenetics: New Perspective on the Ecology, Evolution and Biodiversity of Marine Organisms
Fundamental questions concerning the ecology, evolution and natural history of marine organisms have stood the test of time with respect to their continuing importance and relevance in contemporary marine biol...
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Inhibition of Cysteine and Serine Proteinases by the Cowpox Virus Serpin CRMA
Interleukin lß converting enzyme (ICE) is the founding member of a family of cysteine proteinases active in the metabolism of intracellular proteins [1]. Other members of this family include Ich-1, CPP32, Ced-...
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Stimulation of Human Anti-Viral CD8+ Cytolytic T Lymphocytes by Dendritic Cells
Antigen-specific CD8+ cytolytic T lymphocytes [CTLs] are considered to be important mediators of resistance in several human infections [e.g. influenza (1), HIV-1 (2), cytomegalovirus (3), malaria (4)] and mal...
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Towards the development of a bioartificial pancreas: immunoisolation and NMR monitoring of mouse insulinomas
A promising method for diabetes treatment is the implantation of immunoisolated cells secreting insulin in response to glucose. Cell availability limits the application of this approach at a medically-relevant...
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Expression of Public Idiotypes in Patients with Lyme Arthritis
Joints are often affected in Lyme disease and in some instances this may be due to immune auto-reactivity. To characterise further the immune response in this disease investigations were carried out to determi...
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Inhibition of Aquatic Birnavirus Replication Process in Fish Cells by Viral Antisense RNA
In order to study the inhibitory effect of viral antisense RNAs upon the replication of infectious pancreatic necrosis virus (IPNV) in fish cells. We used three fragments of IPNV-E1S virus cDNA, isolated from ...
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Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin Pharmacokinetics
Current insulin formulations do not mimic the normal glucose-induced release of insulin by the pancreas in a physiological manner.1 One limitation is the delayed absorption of hexameric insulin from the subcutane...
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Correlation of Acute Prostacyclin Response in Primary (Unexplained) Pulmonary Hypertension with Efficacy of Treatment with Calcium Channel Blockers and Survival
Unexplained, or primary, pulmonary hypertension, is usually a rapidly fatal disease, in which the use of vasodilator therapy is controversial (14, 22, 25). While some authors have proposed that there may be a ...
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Application of Electrochemical and UV/Visible Detection to the LC Separation and Determination of Methylene Blue and Its Demethylated Metabolites from Milk
A study was initiated to find a suitable HPLC detection scheme for the determination of methylene blue(MB) in several types of complex animal tissues, milk and milk product matrices. In addition to methylene b...
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The Application of Matrix Solid Phase Dispersion (MSPD) to the Extraction and Subsequent Analysis of Drug Residues in Animal Tissues
The contamination of our environment and of our food supply with industrial, agricultural and pharmaceutical agents possessing toxicologic and/or pharmacologic character are major man-made problems that must b...
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Plutonium, Americtum and Radiocaesium in Sea Water, Sediments and Coastal Soils in Carlingford Lough
Artificial radioactivity within the sediment-water system in Carlingford Lough has been studied and the extent of transport of plutonium from sea to land has been assessed by analysing soil samples taken at se...
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Protein C: Gene Structure and Protein Synthesis
Protein C is a vitamin K-dependent plasma glycoprotein that, after activation by thrombin-thrombomodulin upon the endothelial cell surface, serves as a feedback down-regulator of the coagulation cascade by spe...
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Biosynthesis and Endocytosis of Yolk Proteins in the Mosquito
The maturation of insect eggs requires the fat body production of large amounts of a protein, vitellogenin (Vg), that is secreted into the hemolymph, selectively accumulated by the oocytes and stored in yolk b...
