12 Result(s)
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Alexander S. Raikhel
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Article
Open AccessLeucine aminopeptidase1 controls egg deposition and hatchability in male Aedes aegypti mosquitoes
Aedes aegypti are vectors for several arboviruses infecting hundreds of millions of people annually. Controlling mosquito populations by regulating their reproduction is a potential strategy to minimize viral tra...
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Article
Open AccessImproved reference genome of Aedes aegypti informs arbovirus vector control
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquito...
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Article
Ligand-binding domains in vitellogenin receptors and other LDL-receptor family members share a common ancestral ordering of cysteine-rich repeats
Insect vitellogenin and yolk protein receptors (VgR/YPR) are newly discovered members of the low-density lipoprotein receptor (LDLR) family, which is characterized by a highly conserved arrangement of repetiti...
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Article
Internalization and recycling of vitellogenin receptor in the mosquito oocyte
The major yolk protein precursor in mosquito oocytes, vitellogenin (Vg), is internalized by a 205-kDa membrane-bound receptor (VgR). Recently, VgR has been isolated permitting the production of polyclonal anti...
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Article
Secretory and internalization pathways of mosquito yolk protein precursors
The vitellogenic female fat body of the mosquito Aedes aegypti produces three yolk protein precursors that are deposited in the yolk bodies of develo** oocytes: vitellogenin, vitellogenic carboxypeptidase (VCP)...
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Article
Extensive Sequence Conservation Among Insect, Nematode, and Vertebrate Vitellogenins Reveals Ancient Common Ancestry
The eggs of most oviparous animals are provisioned with a class of protein called vitellogenin (Vg) which is stored as the major component of yolk. Until recently, deduced amino acid sequences were available ...
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Chapter
Culture and analysis of the insect fat body
In insects, the fat body is the centre of intermediate metabolism: it is involved in the metabolism and storage of carbohydrates, lipids, and nitrogenous compounds. Moreover, it is a powerful secretory organ r...
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Culture and analysis of insect ovaries
In insects, a complex of coordinated processes within the ovary contribute to egg maturation. Among the most important are internalization of large quantities of extra-ovarially produced yolk protein precursor...
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Vitellogenesis in Mosquitoes
Malaria, dengue and other mosquito-borne infections are among the most devastating diseases (57, 144). The maintenance and dispersal of mosquito-borne disease depends upon the successful reproduction of the mo...
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Article
A novel protein produced by the vitellogenic fat body and accumulated in mosquito oocytes
The fat body of vitellogenic mosquitoes was found to synthesize and secrete another protein in addition to vitellogenin, that accumulated in develo** oocytes. In the tissues, this protein has Mr = 53000 on SDS-...
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Biosynthesis and Endocytosis of Yolk Proteins in the Mosquito
The maturation of insect eggs requires the fat body production of large amounts of a protein, vitellogenin (Vg), that is secreted into the hemolymph, selectively accumulated by the oocytes and stored in yolk b...
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Article
Mosquito trypsin: immunocytochemical localization in the midgut of blood-fed Aedes aegypti (L.)
A polyclonal antibody was raised against trypsin purified from the midgut of blood-fed Aedes aegypti. Using this antibody and our modification of the peroxidase-antiperoxidase immunocytochemical reaction, strong ...
