Abstract
Antigen-specific CD8+ cytolytic T lymphocytes [CTLs] are considered to be important mediators of resistance in several human infections [e.g. influenza (1), HIV-1 (2), cytomegalovirus (3), malaria (4)] and malignant diseases [e.g. melanoma (5)]. Vaccines or immunotherapies that preferentially prime this arm of the immune response could be essential for effective host immunity. However, the cellular requirements for eliciting specific and potent CTLs from human lymphocytes are not well defined, even in tissue culture where repetitive stimulation with antigen and exogenous cytokines are often required.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
McMichael, A.J., F.M. Gotch, G.R. Noble, and P.A.S. Beare. 1983. Cytotoxic T-cell immunity to influenza. N. Engl. J. Med. 309:13–17.
Koup, R.A., C.A. Pikora, K. Luzuriaga, D.B. Brettler, E.S. Day, G.P. Mazzara, and J.L. Sullivan. 1991. Limiting dilution analysis of cytotoxic T lymphocytes to human immunodeficiency virus gag antigens in infected persons: in vitro quantitation of effector cell populations with pl7 and p24 specificities. J. Exp. Med. 174:1593–1600.
Riddell, S.R., K.S. Watanabe, J.M. Goodrich, C.R. Li, M.E. Agha, and P.D. Greenberg. 1992. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257:238–241.
Hill, A.V.S., J. Elvin, A.C. Willis, M. Aidoo, C.E.M. Allsopp, F.M. Gotch, X.M. Gao, M. Takiguchi, B.M. Greenwood, A.R.M. Townsend, A.J. McMichael, and H.C. Whittle. 1992. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360:434–439.
Van Der Bruggen, P., C. Traversari, P. Chomez, C. Lurquin, E. De Plaen, B. Van Den Eynde, A. Knuth, and T. Boon. 1991. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254:1643–1647.
Young, J.W. and R.M. Steinman. 1990. Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells. J. Exp. Med. 171:1315–1332.
Nonacs, R., C. Humborg, J.P. Tarn, and R.M. Steinman. 1992. Mechanisms of mouse spleen dendritic cell function in the generation of influenza-specific, cytolytic T lymphocytes. J. Exp. Med. 176:519–529.
Macatonia, S.E., P.M. Taylor, S.D. Knight, and B.A. Askonas. 1989. Primary stimulation by dendritic cells induces and-viral proliferative and cytotoxic T cell responses in vitro. J. Exp. Med. 169:1255–1264.
Bhardwaj, N., A. Bender, N. Gonzalez, L.K. Bui, M. Garrett, and R.M. Steinman. 1994. Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells. J. Clin. Invest. 94:797–807.
Peschke, T., A. Bender, M. Nain, and D. Gemsa. 1993. Role of macrophage cytokines in influenza A virus infections. Immunobiol. 189:340–355.
Fesq, H., M. Bacher, M. Nain, and D. Gemsa. 1994. Programmed cell death (apoptosis) in human monocytes infected by influenza virus. Immunobiol. 190:175–182.
McMichael, A.J. and B.A. Askonas. 1978. Influenza virus-specific cytotoxic T cells in man; induction and properties of the cytotoxic cell. Eur. J. Immunol. 8:705–711.
Inaba, K., J.W. Young, and R.M. Steinman. 1987. Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells. J. Exp. Med. 166:182–194.
Domanico, S.Z. and S.K. Pierce. 1992. Virus infection blocks the processing and presentation of exogenous antigen with the major histocompatibility complex class II molecules. Eur. J. Immunol. 22:2055–2062.
Morrison, L.A., A.E. Lukacher, V.L. Braciale, D.P. Fan, and T.J. Braciale. 1986. Differences in antigen presentation to MHC class I-and class II-restricted influenza virus-specific cytolytic T lymphocyte clones. J. Exp. Med 163:903–921.
Kaplan, D.R., R. Griffith, V.L. Braciale, and T.J. Braciale. 1984. Influenza virus-specific human cytotoxic T cell clones: Heterogeneity in antigenic specificity and restriction by class II MHC products. Cell. Immunol. 88:193–206.
Cerundolo, V., A.G.D. Tse, R.D. Salter, P. Parham, and A. Townsend. 1991. CD8 independence and specificity of cytotoxic T lymphocytes restricted by HLA-Aw68.1. Proc. Roy. Soc. London ser B 244:169–177
Hengel, H., M. Lindner, H. Wagner, and K. Heeg. 1987. Frequency of herpes simplex virus-specific murine cytotoxic T lymphocyte precursors in mitogen-and antigen-driven primary in vitro T cell responses. J. Immunol. 139:4196–4202.
Kast, W.M., C.J.P. Boog, B.O. Roep, A.C. Voordouw, and C.J.M. Melief. 1988. Failure or success in the restoration of virus-specific cytotoxic T lymphocyte response defects by dendritic cells. J. Immunol. 140:3186–3193.
Macatonia, S.E., S. Patterson, and S.C. Knight. 1991. Primary proliferative and cytotoxic T cell response to HIV induced in vitro by human dendritic cells. Immunol. 74:399–406.
Bhardwaj, N., J.W. Young, A.J. Nisanian, J. Baggers, and R.M. Steinman. 1993. Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses. J. Exp. Med. 178:633–642.
Young, J.W., L. Koulova, S.A. Soergel, E.A. Clark, R.M. Steinman, and B. Dupont. 1992. The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro. J. Clin. Invest. 90:229–237.
Harding, F.A. and J.P. Allison. 1993. CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help. J. Exp. Med. 177:1791–1796.
Fraser, J.D., M.E. Newton, and A. Weiss. 1992. CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. J. Exp. Med. 175:1131–1134.
Fraser, J.D., B.A. Irving, G.R. Crabtree, and A. Weiss. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313–316.
Thompson, C.B., T. Lindsten, J.A. Ledbetter, S.L. Kunkel, H.A. Young, S.G. Emerson, J.M. Leiden, and C.H. June. 1989. CD28 activation pathway regulates the production of multiple T cell-derived lymphokines/cytokines. Proc. Natl. Acad Sci. USA 86:1333–1337.
Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Ann. Rev. Immunol. 9:271–296.
Inaba, K., J.P. Metlay, M.T. Crowley, and R.M. Steinman. 1990. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J. Exp. Med. 172:631–640.
Takahashi, H., Y. Nakagawa, K. Yokomuro, and J.A. Berzofsky. 1993. Induction of CD8+ cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells. Int. Immunol. 5:849–857.
Nair, S., F. Zhou, R. Reddy, L. Huang, and B.T. Rouse. 1992. Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. J. Exp. Med. 175:609–612.
Wiley, D.C., LA. Wilson, and J.J. Skehel. 1981. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 289:373.
Li, S., M. Rodrigues, D. Rodriguez, J.R. Rodriguez, M. Esteban, P. Palese, R.S. Nussenzweig, and F. Zavala. 1993. Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria. Proc. Natl. Acad. Sci. USA 90:5214–5218.
Carmichael, A., X. **, P. Sissons, and L. Borysiewicz. 1993. Quantitative analysis of the human HIV-1 specific cytotoxic T lymphocyte [CTL] response at different stages of HIV-1 infection: Differential CTL response to HIV-1 and Epstein-Barr virus in late disease. J. Exp. Med. 177:249–256.
Johnson, R.P., A. Trocha, T.M. Buchanan, and B.D. Walker. 1992. Identification of overlap** HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: Definition of minimum epitopes and analysis of the effects of sequence variation. J. Exp. Med. 175:961–971.
Brichard, V., A. Van Pel, T. Wolfel, C. Wolfel, E. De Plaen, B. Lethe, P. Coulie, and T. Boon. 1993. The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. Exp. Med. 178:489–495.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Bhardwaj, N., Bender, A., Gonzalez, N., Bui, L.K., Garrett, M.C., Steinman, R.M. (1995). Stimulation of Human Anti-Viral CD8+ Cytolytic T Lymphocytes by Dendritic Cells. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_84
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1971-3_84
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5811-4
Online ISBN: 978-1-4615-1971-3
eBook Packages: Springer Book Archive