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Article
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation
An allosteric activator of Hsp70 mimics Hip and reduces neurotoxicity in a model for spinobulbar muscular atrophy by promoting ubiquitination and degradation of oligomeric polyglutamine-containing clients. ...
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Inhibition of Cysteine and Serine Proteinases by the Cowpox Virus Serpin CRMA
Interleukin lß converting enzyme (ICE) is the founding member of a family of cysteine proteinases active in the metabolism of intracellular proteins [1]. Other members of this family include Ich-1, CPP32, Ced-...
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Article
Amino acid sequences of ovomucoid third domains from 27 additional species of birds
Ovomucoids consist of a single polypeptide chain which is composed of three tandem Kazal domains. Each Kazal domain is an actual or putative protein inhibitor of serine proteinases. Ovomucoid third domains wer...
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Article
Effect of Enzymic Hydrolysis of the Scissile Bond on the Secondary Structure of a Dimeric Globular Protein
In order to examine the effect of enzymic cleavage of the reactive site on the secondary structure of the globular protein, Streptomyces subtilisin inhibitor, we studied the thermal denaturation of the moderated ...
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Article
Existence of Concanavaline A Type β-Sheet Structure Shown by Reduction of Disulfide Bonds of a Dimeric Globular Protein
