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146 Result(s)
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Article
Open AccessRisk of diabetes mellitus based on the interactive association between G6PD rs72554664 polymorphism and sex in Taiwan Biobank individuals
The presence of glucose-6-phosphate dehydrogenase (G6PD) deficiency may increase the risk of type 2 diabetes mellitus (T2DM), with differing prevalence between males and females. Although G6PD deficiency is an X-...
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Article
Open AccessProdrug-conjugated tumor-seeking commensals for targeted cancer therapy
Prodrugs have been explored as an alternative to conventional chemotherapy; however, their target specificity remains limited. The tumor microenvironment harbors a range of microorganisms that potentially serv...
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Open AccessPredicting early mortality and severe intraventricular hemorrhage in very-low birth weight preterm infants: a nationwide, multicenter study using machine learning
Our aim was to develop a machine learning-based predictor for early mortality and severe intraventricular hemorrhage (IVH) in very-low birth weight (VLBW) preterm infants in Taiwan. We collected retrospective ...
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Open AccessProteomic analysis of serum extracellular vesicles from biliary tract infection patients to identify novel biomarkers
Biliary tract infection (BTI), a commonly occurring abdominal disease, despite being extensively studied for its initiation and underlying mechanisms, continues to pose a challenge in the quest for identifying...
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Open AccessAlkali metal bilayer intercalation in graphene
Alkali metal (AM) intercalation between graphene layers holds promise for electronic manipulation and energy storage, yet the underlying mechanism remains challenging to fully comprehend despite extensive rese...
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Open AccessDual-plasmonic Au@Cu7S4 yolk@shell nanocrystals for photocatalytic hydrogen production across visible to near infrared spectral region
Near infrared energy remains untapped toward the maneuvering of entire solar spectrum harvesting for fulfilling the nuts and bolts of solar hydrogen production. We report the use of Au@Cu7S4 yolk@shell nanocrysta...
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Open AccessEnhanced antioxidant, tyrosinase inhibition, and anti-inflammatory activities of Praeparatum mungo and three of its derivatives
The main objective of this study is to explore the functions of Praeparatum mungo (PM) and three of its derivatives, Praeparatum mungo/turmeric (PM/T), Praeparatum mungo/bromelain (PM/B), and Praeparatum mungo/in...
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Open AccessThermal indices for human biometeorology based on Python
Thermal indices, such as Predicted Mean Vote, Outdoor Standard Effective Temperature, Physiologically Equivalent Temperature, and Universal Thermal Climate Index, are essential for the evaluation of thermal pe...
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Open AccessClinical outcomes between elderly ESKD patients under peritoneal dialysis and hemodialysis: a national cohort study
With ageing populations, new elderly end-stage kidney disease (ESKD) cases rise. Unlike younger patients, elderly ESKD patients are less likely to undergo kidney transplant, and therefore the decision of recei...
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Open AccessA comparative analysis of aerosol exposure and prevention strategies in bystander, pre-hospital, and inpatient cardiopulmonary resuscitation using simulation manikins
To evaluate aerosol exposure risk and prevention strategies during bystander, pre-hospital, and inpatient cardiopulmonary resuscitation (CPR). This study compared hands-only CPR, CPR with a surgical or N95 mas...
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Open AccessTransparent tissue in solid state for solvent-free and antifade 3D imaging
Optical clearing with high-refractive-index (high-n) reagents is essential for 3D tissue imaging. However, the current liquid-based clearing condition and dye environment suffer from solvent evaporation and photo...
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Article
Open AccessMethionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells
Programmed cell death protein 1 (PD-1), expressed on tumor-infiltrating T cells, is a T cell exhaustion marker. The mechanisms underlying PD-1 upregulation in CD4 T cells remain unknown. Here we develop nutrie...
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Open AccessN-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry
Oxidized cysteine residues are highly reactive and can form functional covalent conjugates, of which the allosteric redox switch formed by the lysine-cysteine NOS bridge is an example. Here, we report a noncan...
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Open AccessEndogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration
Inter-cellular movement of “prion-like” proteins is thought to explain propagation of neurodegeneration between cells. For example, propagation of abnormally phosphorylated cytoplasmic inclusions of TAR-DNA-Bi...
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Open AccessThe scaled-invariant Planckian metal and quantum criticality in Ce1−xNdxCoIn5
The mysterious Planckian metal state, showing perfect T-linear resistivity associated with universal scattering rate, 1/τ = αkBT/ℏ with α ~ 1, has been observed in the normal state of various strongly correlated ...
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Open AccessAllele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine...
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Open AccessA feasibility study of wireless inductively coupled surface coil for MR-guided high-intensity focused ultrasound ablation of rodents on clinical MRI systems
Recently, to conduct preclinical imaging research on clinical MRI systems has become an attractive alternative to researchers due to its wide availability, cost, and translational application to clinical human...
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Article
Author Correction: Heterodimensional superlattice with in-plane anomalous Hall effect
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Open AccessAminoglycosides use has a risk of acute kidney injury in patients without prior chronic kidney disease
The outcome of acute kidney injury (AKI) as a result of aminoglycosides (AGs) use remains uncertain in patients without prior chronic kidney disease (CKD). Therefore, we explored the outcomes of AGs use on AKI...
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Heterodimensional superlattice with in-plane anomalous Hall effect
Superlattices—a periodic stacking of two-dimensional layers of two or more materials—provide a versatile scheme for engineering materials with tailored properties1,2. Here we report an intrinsic heterodimensional...