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Open AccessMethionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells
Programmed cell death protein 1 (PD-1), expressed on tumor-infiltrating T cells, is a T cell exhaustion marker. The mechanisms underlying PD-1 upregulation in CD4 T cells remain unknown. Here we develop nutrie...
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Article
Isoquinoline Alkaloids from Corydalis pallida
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Article
Phytochemical Study of the Low Polar Constituents of Pinellia ternata
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Article
Chemical Constituents of the Leaves of Vitis labruscana cv. Steuben
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Article
Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities
Angelica keiskei (Miq.) Koidz. (Umbelliferae) has traditionally been used to treat dysuria, dyschezia, and dysgalactia as well as to restore vitality. Recently, the aerial parts of A. kei...
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Article
Identification of new pyrrole alkaloids from the fruits of Lycium chinense
Three new minor pyrrole alkaloids, 3-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]pentanedioic acid (1), (2R)-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-1-methoxy-1-oxobutanoic acid (2), and methyl (2R)-[2-formyl-...
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Article
Utilization of circular dichroism experiment to distinguish acanthoside D and eleutheroside E
Two lignan glycosides, acanthoside D (1) (=liriodendrin, (+)-syringaresinol di-O-β-d-glucopyranoside) and eleutheroside E (2) have been confused each other for so long time, and hard to be distinguished each othe...
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Article
Separation of two major chalcones from Angelica keiskei by high-speed counter-current chromatography
Angelica keiskei (Shin-sun cho) is an edible higher plant with the beneficial preventive effects on cancer, hypertension, and coronary heart disease. Two bioactive chalcones of Shin-sun c...
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Article
Open AccessInhibitory effects of Stemona tuberosa on lung inflammation in a subacute cigarette smoke-induced mouse model
Stemona tuberosa has long been used in Korean and Chinese medicine to ameliorate various lung diseases such as pneumonia and bronchitis. However, it has not yet been proven that Stemona tuberosa has positive eff...