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  1. Article

    Open Access

    Transparent tissue in solid state for solvent-free and antifade 3D imaging

    Optical clearing with high-refractive-index (high-n) reagents is essential for 3D tissue imaging. However, the current liquid-based clearing condition and dye environment suffer from solvent evaporation and photo...

    Fu-Ting Hsiao, Hung-Jen Chien, Ya-Hsien Chou, Shih-Jung Peng… in Nature Communications (2023)

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  2. Article

    Local islet remodelling associated with duct lesion–islet complex in adult human pancreas

    Islets are thought to be stably present in the adult human pancreas to maintain glucose homeostasis. However, identification of the pancreatic intraepithelial neoplasia (PanIN)–islet complex in mice and the pr...

    Yu-Wen Tien, Hung-Jen Chien, Tsai-Chen Chiang, Mei-Hsin Chung… in Diabetologia (2021)

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  3. Article

    Pancreatic neuro-insular network in young mice revealed by 3D panoramic histology

    It has been proposed that the neuro-insular network enables rapid, synchronised insulin secretion. However, to date, acquiring the pancreatic tissue map to study the neural network remains a challenging task a...

    Shiue-Cheng Tang, Chia-Ning Shen, Pei-Yu Lin, Shih-Jung Peng… in Diabetologia (2018)

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