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Article
Open AccessMethionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells
Programmed cell death protein 1 (PD-1), expressed on tumor-infiltrating T cells, is a T cell exhaustion marker. The mechanisms underlying PD-1 upregulation in CD4 T cells remain unknown. Here we develop nutrie...
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Article
Open AccessAMPK suppresses Th2 cell responses by repressing mTORC2
Allergic inflammation is a T helper 2 (Th2) cell-driven pathophysiological phenomenon, but the mechanism by which the metabolic cascade affects Th2 cell differentiation remains unclear. In this study, we inves...
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Article
Open AccessAMPK promotes antitumor immunity by downregulating PD-1 in regulatory T cells via the HMGCR/p38 signaling pathway
AMP-activated protein kinase (AMPK) is a metabolic sensor that maintains energy homeostasis. AMPK functions as a tumor suppressor in different cancers; however, its role in regulating antitumor immunity, parti...
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Article
LKB1-PTEN axis controls Th1 and Th17 cell differentiation via regulating mTORC1
Immuno-environmental change triggers CD4+ T cell differentiation. T cell specialization activates metabolic signal pathways to meet energy requirements. Defective T cell-intrinsic metabolism can aggravate immunop...
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Article
Using spectral analysis and multinomial logit regression to explain households’ choice patterns
Many methods are available to analyze rank-ordered data. We used spectral analysis to identify the most preferred option of Formosan subterranean termites (FSTs) control as ranked by Louisiana homeowners. Resp...
