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Article
Open AccessLocalized fine-tuning and clinical evaluation of deep-learning based auto-segmentation (DLAS) model for clinical target volume (CTV) and organs-at-risk (OAR) in rectal cancer radiotherapy
Various deep learning auto-segmentation (DLAS) models have been proposed, some of which have been commercialized. However, the issue of performance degradation is notable when pretrained models are deployed in...
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Article
Multi-omics portrait of ductal carcinoma in situ in young women
Young patients with breast ductal carcinoma in situ (DCIS) often face a poorer prognosis. The genomic intricacies in young-onset DCIS, however, remain underexplored.
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Article
Open AccessPyrotinib and trastuzumab plus palbociclib and fulvestrant in HR+/HER2+ breast cancer patients with brain metastasis
Human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) patients are at a high risk of develo** metastases in the brain. However, research focusing on treatment strategies for hormonal r...
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Article
Open AccessGenetic analysis of oligo-recurrence breast cancer: correlation with clinical outcomes
We aimed to identify the relationship between the genomic characteristics and clinical outcomes of oligo-metastatic breast cancer.
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Article
Analysis of the influential factors of the emotional health of patients with cancer based on the structural equation model: the role of social media and emotional support
To explore the mental health status of patients with cancer and related influential factors and provide a scientific basis to reduce serious emotional problems, improve the quality of life of cancer survivors ...
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Article
Open AccessThe interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms
N6-methyladenosine(m6A) is one of the most abundant modifications of mammalian cellular RNAs. m6A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, transl...
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Article
Open AccessThe prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer
This study aimed to investigate the prognostic value of AR in HER2+ nonmetastatic breast invasive ductal carcinoma (IDC) and its relationship with the immune microenvironment. HER2+ nonmetastatic breast IDC pa...
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Article
Long-term survival after sentinel lymph node biopsy or axillary lymph node dissection in pN0 breast cancer patients: a population-based study
Findings from randomized clinical trials have shown that survival in patients with sentinel lymph node (SLN)-negative breast cancer is noninferior with SLN biopsy (SLNB) alone versus further axillary lymph nod...
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Article
Efficacy and steroid-sparing effect of tacrolimus in patients with autoimmune cytopenia
The aim of this study was to evaluate the efficacy, safety, and steroid-sparing effect of tacrolimus in patients with autoimmune cytopenia, including immune thrombocytopenia (ITP), autoimmune hemolytic anemia ...
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Article
The Role of Sentinel Lymph Node Map** in High-grade Endometrial Cancer
Total hysterectomy with lymph node assessment is the current standard-of-care for surgical staging in apparent early-stage endometrial cancer. Compared to the traditional complete pelvic lymphadenectomy with o...
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Article
Open AccessNail pigmentation induced by chemotherapy: an observational study of patients with early-stage breast cancer
Chemotherapy-induced nail pigmentation is a common adverse effect, but prospective studies focussing on its onset, recovery, and severity are few. We aim to evaluate the pattern of chemotherapy-induced nail pi...
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Article
Open AccessThe diagnostic and prognostic implications of PRKRA expression in HBV-related hepatocellular carcinoma
Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) accounts for more than half of total HCC patients in develo** countries. Currently, HBV-related HCC diagnosis and prognosis still lack specific ...
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Article
Open AccessRetro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma
Glioblastoma (GBM), one of the most common primary intracranial malignant tumours, is very difficult to be completely excised by surgery due to its irregular shape. Here, we use an MRI/NIR fluorescence dual-mo...
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Article
Open AccessThe STING1 network regulates autophagy and cell death
Cell death and immune response are at the core of life. In past decades, the endoplasmic reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a fundamental role in the production of...
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Article
Open AccessCPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4
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Open AccessComorbidity in lung cancer patients and its association with hospital readmission and fatality in China
Comorbidity has been established as one of the important predictors of poor prognosis in lung cancer. In this study, we analyzed the prevalence of main comorbidities and its association with hospital readmissi...
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Article
Open AccessComorbidity in lung cancer patients and its association with medical service cost and treatment choice in China
It is evident that comorbidity exacerbate the complexity of the management of lung cancer, however, limited research has been conducted to investigate the impact of comorbidity on health service utilization an...
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Article
Open AccessSystemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma
Gene-modified autologous T cells expressing NY-ESO-1c259, an affinity-enhanced T-cell receptor (TCR) reactive against the NY-ESO-1-specific HLA-A*02-restricted peptide SLLMWITQC (NY-ESO-1 SPEAR T-cells; GSK 794),...
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Article
Effects of Different Forms and Levels of Selenomethionine on Productive Performance and Antioxidant Status of Broiler Breeders and Its Offspring
This study was conducted to investigate the effects of different selenomethionine (SM) forms and levels on productive performance and antioxidant status of broiler breeders and its offspring. Four hundred eigh...
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Article
Pretreatment anti-Mullerian hormone-based nomogram predicts menstruation status after chemotherapy for premenopausal women with hormone receptor-positive early breast cancer
Ovarian function is important for optimizing endocrine treatment in patients with hormone receptor-positive (HR+) early breast cancer (eBC). The aim of the study was to determine whether patients’ pretreatment...