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Article
Open AccessFerroptosis: principles and significance in health and disease
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecular networks involving diverse molecules and organelles. Since its recognition as a non-...
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Article
Open AccessFerroptotic therapy in cancer: benefits, side effects, and risks
Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular content release. Originally investigat...
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Article
LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth
The mechanisms underlying the dynamic remodelling of cellular membrane phospholipids to prevent phospholipid peroxidation-induced membrane damage and evade ferroptosis, a non-apoptotic form of cell death drive...
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Article
Targeting cuproplasia and cuproptosis in cancer
Copper, an essential trace element that exists in oxidized and reduced forms, has pivotal roles in a variety of biological processes, including redox chemistry, enzymatic reactions, mitochondrial respiration, ...
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Article
Diverse functions of cytochrome c in cell death and disease
The redox-active protein cytochrome c is a highly positively charged hemoglobin that regulates cell fate decisions of life and death. Under normal physiological conditions, cytochrome c is localized in the mitoch...
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Article
ATF4 in cellular stress, ferroptosis, and cancer
Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response element-binding (CREB) family, plays a critical role as a stress-induced transcription factor. It orchestrates cellular responses, pa...
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Article
Targeting paraptosis in cancer: opportunities and challenges
Cell death can be classified into two primary categories: accidental cell death and regulated cell death (RCD). Within RCD, there are distinct apoptotic and non-apoptotic cell death pathways. Among the various...
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Article
A guideline on the molecular ecosystem regulating ferroptosis
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnesse...
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Article
Correction: The KRAS-G12C inhibitor: activity and resistance
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Article
The multifunctional protein HMGB1: 50 years of discovery
Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin, HMGB1 is now known to regulate diverse biological processes depending on its subcellular or extracellular localiza...
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Article
Open AccessEP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer
Ferroptosis is a form of regulated cell death characterized by oxidative injury-induced lipid peroxidation. However, the detailed protein post-translational modification regulatory mechanism of ferroptosis rem...
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Article
Open AccessLiver in infections: a single-cell and spatial transcriptomics perspective
The liver is an immune organ that plays a vital role in the detection, capture, and clearance of pathogens and foreign antigens that invade the human body. During acute and chronic infections, the liver transf...
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Article
Reductive cell death: the other side of the coin
The balance between oxidants and antioxidants within cells, known as redox homeostasis, is crucial for proper cellular function. Disruption of redox homeostasis has been implicated in the development and treat...
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Article
Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have ...
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Article
Glimmers of hope for targeting oncogenic KRAS-G12D
KRAS mutations are one of the most common genetic abnormalities in cancer, especially lung, colon, and pancreatic cancers. Strategies targeting the oncogenic KRAS pathway include direct and indirect approaches. K...
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Article
Open AccessACSS2-mediated NF-κB activation promotes alkaliptosis in human pancreatic cancer cells
Alkaliptosis is a recently discovered type of pH-dependent cell death used for tumor therapy. However, its underlying molecular mechanisms and regulatory networks are largely unknown. Here, we report that the ...
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Protocol
Monitoring Mitochondria Function in Ferroptosis
Ferroptosis is a type of regulated necrosis driven by uncontrolled membrane lipid peroxidation. Mitochondria, which are membrane-bound organelles present in almost all eukaryotic cells and play a central role ...
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Protocol
Fluorogenic Probes for Intracellular Iron Detection
Iron is a crucial element required to sustain multiple biological processes, including oxygen transport, DNA synthesis, and electron transport. In living cells, iron exists as either ferrous iron (Fe2+) or ferric...
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Protocol
Organoids Models of Pancreatic Duct Adenocarcinoma
Three-dimensional (3D) organoid culture is a laboratory technique used to grow and study miniature organs that mimic the structure and function of real organs in the human body. Organoids are created from stem...
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Protocol
Monitoring Lysosome Function in Ferroptosis
Ferroptosis is a type of regulated cell death that occurs due to iron-induced membrane lipid peroxidation. Lysosomes, which are acidic, membrane-bound organelles containing various hydrolases, play a vital rol...
