-
Article
Correction: TJ-M2010-5 Attenuates Severe Myocardial Ischemia/Reperfusion Injury in Heart Transplantation by Inhibiting MyD88 Homodimerization In Vivo
-
Article
Quantitative MRI of liver grafts for assessment of macrovesicular steatosis ex vivo and long-term follow-up outcomes
To indicate whether ex vivo magnetic resonance imaging (MRI)-proton density fat fraction (PDFF) could be advantageous for selection of liver grafts and to achieve information about pre-transplant indicators of...
-
Article
Open AccessL-carnitine promotes liver regeneration after hepatectomy by enhancing lipid metabolism
Lipid metabolism plays an important role in liver regeneration, but its regulation still requires further research. In this study, lipid metabolites involved in mouse liver regeneration at different time point...
-
Article
Individualized Biliary Reconstruction Techniques in Liver Transplantation: Five Years’ Experience of a Single Institution
To summarize the experience of individualized biliary reconstruction techniques in deceased donor liver transplantation and explore potential risk factors for biliary stricture.
-
Article
TJ-M2010-5 Attenuates Severe Myocardial Ischemia/Reperfusion Injury in Heart Transplantation by Inhibiting MyD88 Homodimerization In Vivo
Survival of transplanted hearts is often limited by cold ischemia time. Here, we assessed the effects of the small molecular compound TJ-M2010-5 on graft preservation. In a cardiac cold ischemia/reperfusion mo...
-
Article
Open AccessKdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus
Kdm2a catalyzes H3K36me2 demethylation to play an intriguing epigenetic regulatory role in cell proliferation, differentiation, and apoptosis. Herein we found that myeloid-specific knockout of Kdm2a (LysM-Cre-Kdm...
-
Article
Subjective life expectancy and associated factors among cancer survivors over 45 years old: evidence from the CHARLS
Associations between subjective life expectancy (SLE) and a variety of factors are well documented, but the relationship regarding cancer is limited. The purpose of this study was to disclose this potential re...
-
Article
Open AccessComorbidity in lung cancer patients and its association with hospital readmission and fatality in China
Comorbidity has been established as one of the important predictors of poor prognosis in lung cancer. In this study, we analyzed the prevalence of main comorbidities and its association with hospital readmissi...
-
Article
SUMOylation of Pdia3 exacerbates proinsulin misfolding and ER stress in pancreatic beta cells
SUMOylation has long been recognized to regulate multiple biological processes in pancreatic beta cells, but its impact on proinsulin disulfide maturation and endoplasmic reticulum (ER) stress remains elusive....
-
Article
Open AccessCorrection to: A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model
Following publication of the original article [1], one of the funding was missing in the Funding section.
-
Article
Open AccessExtracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability
High-mobility group box 1 (HMGB1), an evolutionarily conserved chromosomal protein, was rediscovered to be a ‘danger signal’ (alarmin) that alerts the immune system once released extracellularly. Therefore, it...
-
Article
Open AccessComorbidity in lung cancer patients and its association with medical service cost and treatment choice in China
It is evident that comorbidity exacerbate the complexity of the management of lung cancer, however, limited research has been conducted to investigate the impact of comorbidity on health service utilization an...
-
Article
Open AccessAutophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice
Helix B surface peptide (HBSP) is an erythropoietin (EPO)-derived peptide that protects tissue from the risks of elevated blood pressure and thrombosis. This study focused on the protection of HBSP in hepatic ...
-
Article
Open AccessA novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model
Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion...
-
Article
Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function
Post-translational attachment of a small ubiquitin-like modifier (SUMO) to the lysine (K) residue(s) of target proteins (SUMOylation) is an evolutionary conserved regulatory mechanism. This modification has pr...
-
Chapter
Sumoylation Modulates the Susceptibility to Type 1 Diabetes
Susceptibility to type 1 diabetes (T1D) is determined by interactions of multiple genes with environmental triggers. Thus far, more than 50 T1D susceptibility regions have been suggested from genetic studies b...
-
Article
Effects of resistant and susceptible rubber germplasms on development, reproduction and protective enzyme activities of Eotetranychus sexmaculatus (Acari: Tetranychidae)
Systematic research or technical support regarding rubber germplasm resistance against mites was not performed yet. To develop a preliminary understanding of the mite-resistance mechanisms of rubber germplasms...
-
Article
Effects of heat stress on development, reproduction and activities of protective enzymes in Mononychellus mcgregori
Mononychellus mcgregori is a pest mite of cassava. Since its invasion into China in 2008 it has spread rapidly. In order to determine the potential distribution and to analyze its invasion, diffu...
-
Article
Open AccessTargeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma
Robust ERK1/2 activity, which frequently results from KRAS mutation, invariably occurs in pancreatic ductal adenocarcinoma (PDAC). However, direct interference of KRAS signaling has not led to clinically succe...
-
Article
Successful kidney transplantation in highly sensitized patients
Highly sensitized patients experience an increased number of rejection episodes and have poorer graft survival rates; hence, sensitization is a significant barrier to both access to and the success of organ tr...
