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  1. Article

    Open Access

    Identification of Treatment Efficacy-Related Host Factors in Chronic Hepatitis C by ProteinChip Serum Analysis

    Recent development of proteomic array technology, including protein profiling coupling ProteinChip array with surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF/MS), provi...

    Naoki Fujita, Mamoru Nakanishi, Jun Mukai, Yuuji Naito… in Molecular Medicine (2011)

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  2. No Access

    Article

    Influence of phlebotomy on iron-related gene expression levels in the livers of patients with chronic hepatitis C

    Naoki Fujita, Ryosuke Sugimoto, Naohito Urawa… in Journal of Gastroenterology (2007)

  3. Article

    Unidentified virus-like particles are detected in plasmas with elevated ALT levels: are they significant of etiological agent(s) of non-B, non-C hepatitis?

    GB virus C (GBV-C) and hepatitis G virus (HGV) have been proposed as new viruses etiologically implicated in non-B, non-C hepatitis, but the morphology of these particular virus particles is still unknown, and...

    Masahiko Kaito, Hideaki Tanaka, Shinichiro Horiike… in Medical Molecular Morphology (2007)

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  4. Article

    Open Access

    Hepcidin Expression in the Liver: Relatively Low Level in Patients with Chronic Hepatitis C

    Patients with chronic hepatitis C frequently have serum and hepatic iron overload, but the mechanism is unknown. Recently identified hepcidin, exclusively synthesized in the liver, is thought to be a key regul...

    Naoki Fujita, Ryosuke Sugimoto, Masaki Takeo, Naohito Urawa… in Molecular Medicine (2007)

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  5. No Access

    Article

    Iron reduction therapy by phlebotomy reduces lipid peroxidation and oxidative stress in patients with chronic hepatitis C

    Masahiko Kaito, Motoh Iwasa, Yoshinao Kobayashi… in Journal of Gastroenterology (2006)

  6. No Access

    Article

    Immune complex of hepatitis C virus particles detected by immunogold electron microscopy

    Masahiko Kaito, Esteban C Gabazza, Naoki Fujita… in Journal of Gastroenterology (2006)

  7. No Access

    Article

    The ultrastructural morphology of native hepatitis B virus

    Cell lines (2.2.15 cells) capable of supporting the replication of hepatitis B virus (HBV) DNA and intact viral particles have been established by HBV DNA transfection into HepG2 cells. The purpose of this stu...

    Masahiko Kaito, Hiroyoshi Ohba, Joe Chiba, Michinori Kohara… in Medical Molecular Morphology (2006)

  8. No Access

    Article

    Iron content and consumption of health foods by patients with chronic hepatitis C

    Kazuko Iwata, Motoh Iwasa, Nagisa Hara, Aki Matsumoto… in Journal of Gastroenterology (2006)

  9. No Access

    Article

    Accumulation of 8-n itroguanine in the liver of chronic hepatitis C patients without sustained virological response after completion of interferon therapy

    Masahiko Kaito, Shinichiro Horiike, Hideaki Tanaka… in Journal of Gastroenterology (2006)

  10. No Access

    Article

    Hepatotoxicity associated with Lyophyllum decastes Sing. (Hatakeshimeji)

    Motoh Iwasa, Masahiko Kaito, Shinichiro Horiike… in Journal of Gastroenterology (2006)

  11. No Access

    Article

    Morphology of hepatitis C and hepatitis B virus particles as detected by immunogold electron microscopy

    We performed indirect immunogold electron microscopy (EM) for immunological identification and characterization of hepatitis C virus (HCV). To clarify the morphology of HCV, an indirect immunogold EM of two pl...

    Masahiko Kaito, Satoshi Ishida, Hideaki Tanaka… in Medical Molecular Morphology (2006)

  12. No Access

    Article

    Evaluation of Cingulate Gyrus Blood Flow in Patients With Liver Cirrhosis

    Although neuropsychological tests are commonly applied to detect minimal hepatic encephalopathy (HE) in patients with liver cirrhosis (LC), they provide no information about the cerebral regions involved. Rece...

    Motoh Iwasa, Kaname Matsumura, Yuri Nakagawa, Mika Yamamoto… in Metabolic Brain Disease (2005)

  13. No Access

    Article

    Dubin-Johnson-like black liver with normal bilirubin level

    Black liver is a common finding in Dubin-Johnson syndrome (DJS), which is caused by the lack of multidrug resistance-associated protein 2 (MRP2). Impaired excretion of epinephrine metabolites is believed to be...

    Yoshinao Kobayashi, Tomoaki Ishihara, Morimasa Wada… in Journal of Gastroenterology (2004)

  14. No Access

    Article

    A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trial in Japan

    Increasing evidence indicates that iron cytotoxicity plays an important role in the pathogenesis of chronic hepatitis C (CHC). However, the biochemical effects of iron reduction therapy on CHC remain to be con...

    Motoyoshi Yano, Hisao Hayashi, Kentaro Yoshioka… in Journal of Gastroenterology (2004)

  15. No Access

    Article

    Single photon emission computed tomography and statistical parametric map** analysis in cirrhotic patients with and without minimal hepatic encephalopathy

    The early diagnosis and treatment of cognitive impairment in cirrhotic patients is needed to improve the patients’ daily living. In this study, alterations of regional cerebral blood flow (rCBF) were evaluated...

    Yuri Nakagawa, Kaname Matsumura, Motoh Iwasa, Masahiko Kaito… in Annals of Nuclear Medicine (2004)

  16. No Access

    Article

    Ineffective interferon treatment of chronic hepatitis C-associated porphyria cutanea tarda, but with a transient decrease in HCV RNA levels

    Many patients with porphyria cutanea tarda (PCT) have been reported to be hepatitis C virus (HCV) carriers, suggesting that HCV infection plays a role in the pathogenesis of this type of porphyria. In this st...

    Masahiko Furuta, Masahiko Kaito, Esteban Gabazza… in Journal of Gastroenterology (2000)