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  1. No Access

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    Various copper and iron overload patterns in the livers of patients with Wilson disease and idiopathic copper toxicosis

    Wilson disease (WD) is a major type of primary copper toxicosis associated with hypoceruloplasminemia, while idiopathic copper toxicosis (ICT) is a minor type characterized by normoceruloplasminemia. Because c...

    Hisao Hayashi, Ai Hattori, Yasuaki Tatsumi… in Medical Molecular Morphology (2013)

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    Article

    Compound overload of copper and iron in patients with Wilson's disease

    This review of the copper–iron interaction in Wilson's disease was mainly based on ten patients (three females and seven males) studied in our institutes because the genetic tests of ATP7B for Wilson's disease of...

    Hisao Hayashi, Motoyoshi Yano, Yoshikazu Fujita… in Medical Molecular Morphology (2006)

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    Article

    Mutational analysis of the MRP2 gene and long-term follow-up of Dubin-Johnson syndrome in Japan

    Recent studies have indicated that dysfunction or loss of the multidrug resistance protein 2 (MRP2) is the molecular basis of Dubin-Johnson syndrome (DJS). To clarify the genetic basis of the disease and the l...

    Ikuo Machida, Shinya Wakusawa, Fujiko Sanae, Hisao Hayashi… in Journal of Gastroenterology (2005)

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    Improvement of serum bilirubin levels after venesection in a patient with Dubin-Johnson syndrome and HCV-positive chronic liver disease

    Direct-type hyperbilirubinemia in Dubin-Johnson syndrome is due to the genetic dysfunction of multidrug resistance protein 2. However, serum bilirubin levels may fluctuate as a result of acquired conditions. I...

    Ikuo Machida, Shinya Wakusawa, Hisao Hayashi, Satoshi Suzuki… in Journal of Gastroenterology (2004)

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    A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trial in Japan

    Increasing evidence indicates that iron cytotoxicity plays an important role in the pathogenesis of chronic hepatitis C (CHC). However, the biochemical effects of iron reduction therapy on CHC remain to be con...

    Motoyoshi Yano, Hisao Hayashi, Kentaro Yoshioka… in Journal of Gastroenterology (2004)

  6. Article

    Identification of a novel 2026G→C mutation of the MRP2 gene in a Japanese patient with Dubin-Johnson syndrome

    Dubin-Johnson syndrome is a recessive inherited disorder with conjugated hyperbilirubinemia caused by a dysfunction of multidrug resistance protein 2 (MRP2) on the canalicular membrane of hepatocytes. A mutati...

    Shinya Wakusawa, Ikuo Machida, Satoshi Suzuki, Hisao Hayashi… in Journal of Human Genetics (2003)

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    Article

    Ultrastructural identification of iron and copper accumulation in the liver of a male patient with Wilson disease

    There is accumulating evidence that ceruloplasmin, a copper-containing protein with ferroxidase activity, plays an important role in iron metabolism. Reduction of ferroxidase activity secondary to ceruloplasm...

    Yuhta Shiono, H. Hayashi, Shinya Wakusawa, Motoyoshi Yano in Medical Electron Microscopy (2001)

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    Article

    Electron microscopic findings of the liver of a patient with Dubin–Johnson syndrome complicated by chronic hepatitis C and iron overload

    A patient was first found to have Dubin–Johnson syndrome and chronic hepatitis at the age of 25 years. Two years later, he underwent gastrectomy because of massive bleeding from duodenal ulcer, followed by po...

    H. Hayashi, Yoshihiro Imaizumi, Toshikuni Takikawa… in Medical Electron Microscopy (1999)

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    Article

    Hepatotoxic iron storage in patients with chronic hepatitis C but no hepatic iron detectable histochemically

    The accumulation of iron plays a role in the pathogenesis of chronic hepatitis C. Therefore, even slight excesses of iron should be measured if possible. Eight patients were entered in this study who were nega...

    Motoyoshi Yano, Hisao Hayashi, Shinya Wakusawa… in Medical Electron Microscopy (1997)

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    Article

    Correlation between serum levels of alanine aminotransferase and ferritin in male blood donors with antibody to hepatitis C virus

    Chronic hepatitis C has been demonstrated to be associated with hepatic iron overload, and the hypothesis that the disease activity of hepatitis C is associated with iron cytotoxicity was tested in male volunt...

    Toshikuni Takikawa, Hisao Hayashi, Noriko Nishimura… in Journal of Gastroenterology (1994)

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    Article

    Hemangiopericytomatous meningioma metastasized to the liver: Report of a case and review of the literature

    A 54-year-old male was admitted to our hospital for treatment of a liver tumor which was pointed out by screening ultrasonography. Computed tomography revealed a tumor in the right lobe of the liver measuring ...

    Tetsuya Kaneko, Akio Harada, Koichi Isshiki, Hiroya Murakami… in Surgery Today (1993)