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  1. Article

    Open Access

    A simple and useful method for evaluation of oxidative stress in vivo by spectrofluorometric estimation of urinary pteridines

    Pteridine derivatives are intermediate metabolites of folic acid and its cofactors. Oxidized-form pteridines, but not reduced-form pteridines, are fluorescent substances. The purpose of this study was to clari...

    Ichiro Wakabayashi, Mamoru Nakanishi, Makoto Ohki, Akira Suehiro in Scientific Reports (2020)

  2. No Access

    Article

    Impaired expression of the mitochondrial calcium uniporter suppresses mast cell degranulation

    Calcium ion (Ca2+) uptake into the mitochondrial matrix influences ATP production, Ca2+ homeostasis, and apoptosis regulation. Ca2+ uptake across the ion-impermeable inner mitochondrial membrane is mediated by th...

    Tadahide Furuno, Narumi Shinkai, Yoshikazu Inoh in Molecular and Cellular Biochemistry (2015)

  3. No Access

    Protocol

    Analysis of Neuroimmune Interactions by an In Vitro Coculture Approach

    Nerve fibers innervate every organ of the body and are involved in monitoring changes of the external and internal environment. Innervation directly controls a variety of physiological responses in an adaptive...

    Tadahide Furuno, Mamoru Nakanishi in Neuropeptides (2011)

  4. Article

    Open Access

    Identification of Treatment Efficacy-Related Host Factors in Chronic Hepatitis C by ProteinChip Serum Analysis

    Recent development of proteomic array technology, including protein profiling coupling ProteinChip array with surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF/MS), provi...

    Naoki Fujita, Mamoru Nakanishi, Jun Mukai, Yuuji Naito in Molecular Medicine (2011)

  5. No Access

    Article

    Inhibition of degranulation and cytokine production in bone marrow-derived mast cells by hydrolyzed rice bran

    We investigated the effects of hydrolyzed rice bran (HRB), an arabinoxylan extracted from rice bran, on mast cell degranulation and cytokine production.

    Yuka Hoshino, Naohide Hirashima, Mamoru Nakanishi, Tadahide Furuno in Inflammation Research (2010)

  6. No Access

    Article

    Pitavastatin Reduces Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands in Hypercholesterolemic Humans

    The aim of this study was to determine the impact of pitavastatin on low-density lipoprotein cholesterol (LDL-C) and lectin-like oxidized LDL receptor-1 (LOX-1) in patients with hypercholesterolemia. Twenty-fi...

    Tetsuya Matsumoto, Masatoshi Fujita, Tatsuya Sawamura, Akemi Kakino, Yuko Sato in Lipids (2010)

  7. No Access

    Article

    Myeloid sarcoma in essential thrombocythemia that transformed into acute myeloid leukemia

    A 72-year-old man was diagnosed with essential thrombocythemia (ET) and was treated with hydroxyurea for approximately 5 years. He was well until April 2007. In May 2007, a slight fall in hemoglobin levels was...

    Hisaharu Shikata, Takuya Matumoto, Hiroki Teraoka in International Journal of Hematology (2009)

  8. No Access

    Article

    Molecular Basis of Neuroimmune Interaction in an In Vitro Coculture Approach

    A team of researchers from Nagoya, Tokyo and Hamilton developed a unique technique for studying neuroimmune interaction with confocal laser scanning fluorescence microscopy several years ago. It relies on guid...

    Mamoru Nakanishi, Tadahide Furuno in Cellular & Molecular Immunology (2008)

  9. No Access

    Article

    A New Real Time Object Segmentation and Tracking Algorithm and its Parallel Hardware Architecture

    Most of the emerging content-based multimedia technologies are based on efficient methods to solve machine early vision tasks. Among other tasks, object segmentation is perhaps the most important problem in si...

    Mahmound Meribout, Mamoru Nakanishi in Journal of VLSI signal processing systems … (2005)

  10. No Access

    Article

    Cationic Cholesterol Promotes Gene Transfection Using the Nuclear Localization Signal in Protamine

    Purpose. The purpose of this study was to evaluate protamine-mediated gene transfection by liposomes with a novel cationic cholesterol derivative (I) compared to those with DC-Chol or DOTMA (Lipofectin).

    Ari Noguchi, Naohide Hirashima, Mamoru Nakanishi in Pharmaceutical Research (2002)

  11. No Access

    Article

    Serum protein and immunoglobulin levels among nepalese living in southern Nepal

    This study examined the levels of serum protein fractionation, immunoglobulin (Ig) and antistreptolysin O (ASO) of people (91 males and 84 females aged 10–68 years) living in the Terai region of southern Nepal...

    Yoshimi Ohno, Kazuko Hirai, Mamoru Nakanishi in Environmental Health and Preventive Medici… (2002)

  12. No Access

    Article

    A butter diet induces higher levels of n-3 PUFA and of n−3/n−6 PUFA ratio in rat serum and hearts than a safflower oil diet

    The effects of a 47-week diet of butter or safflower oil as fat in combination with casein or soy protein as protein were observed for the serum concentrations of lipids and fatty acid compositions in rat seru...

    Kazuko Hirai, Yuriko Ozeki, Takayo Nakano in Environmental Health and Preventive Medici… (2001)

  13. No Access

    Article

    Real-time CAM-based Hough transform algorithm and its performance evaluation

    Mamoru Nakanishi, Takeshi Ogura in Machine Vision and Applications (2000)

  14. No Access

    Article

    Helicobacter pylori and Mucosal Atrophy in Patients with Gastric Cancer (A Special Study Regarding the Methods for Detecting Helicobacter pylori)

    We assessed the sensitivities of several methodsfor detecting Helicobacter pylori (culture, histology,rapid urease test, and serology), and evaluated the H.pylori positivity considering the degree of atrophy i...

    Hisahiko Tabata, Tadahiko Fuchigami, Hiroyuki Kobayashi in Digestive Diseases and Sciences (1999)

  15. No Access

    Article

    Stopped-flow fluorescence studies on binding of snake neurotoxins to acetylcholine receptor

    The stopped-flow technique has been applied to observe the time dependence of a tryptophanyl fluorescence change upon binding of postsynaptic snake neurotoxins to nicotinic acetylcholine receptor (Narke japonica)...

    Toshiya Endo, Mamoru Nakanishi, Shoei Furukawa in Journal of Protein Chemistry (1987)