-
Article
A lipidome landscape of aging in mice
Understanding the molecular mechanisms of aging is crucial for enhancing healthy longevity. We conducted untargeted lipidomics across 13 biological samples from mice at various life stages (2, 12, 19 and 24 mo...
-
Article
Open AccessProtective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice
Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-β1 is implicated in this activation. I...
-
Article
Open AccessSuperiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease
We recently proposed that mepenzolate bromide (mepenzolate) would be therapeutically effective against chronic obstructive pulmonary disease (COPD) due to its both anti-inflammatory and bronchodilatory activit...
-
Article
Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease
The clinical treatment of chronic obstructive pulmonary disease (COPD) requires not only an improvement of airflow by bronchodilation but also the suppression of emphysema by controlling inflammation. Here we ...
-
Article
Dubin-Johnson-like black liver with normal bilirubin level
Black liver is a common finding in Dubin-Johnson syndrome (DJS), which is caused by the lack of multidrug resistance-associated protein 2 (MRP2). Impaired excretion of epinephrine metabolites is believed to be...
-
Article
Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance
Bilirubin is taken up from blood into hepatocytes by sinosuidal membrane transporters and then excreted into bile through the bile canalicular membrane mainly as bilirubin glucuronides. (1) Mechanism of bilir...
