9 Result(s)

Article

BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer

This study reports that most patients with NSCLC had a significant increase in the nAb response to the currently circulating Omicron variants after bivalent booster vaccination and had Ab titers comparable to ...

Rajesh M. Valanparambil, Lilin Lai, Margaret A. Johns… in npj Vaccines (2023)

Article

Author Correction: Systems vaccinology of the BNT162b2 mRNA vaccine in humans

Prabhu S. Arunachalam, Madeleine K. D. Scott, Thomas Hagan, Chunfeng Li… in Nature (2023)

Article

Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice

Adjuvants enhance the magnitude and the durability of the immune response to vaccines. However, there is a paucity of comparative studies on the nature of the immune responses stimulated by leading adjuvant ca...

Lilit Grigoryan, Audrey Lee, Alexandra C. Walls, Lilin Lai, Benjamin Franco… in npj Vaccines (2022)

Article

mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates

B.1.351 is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant most resistant to antibody neutralization. We demonstrate how the dose and number of immunizations influence protection. Nonh...

Kizzmekia S. Corbett, Anne P. Werner, Sarah O’ Connell, Matthew Gagne… in Nature Immunology (2021)

Article

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

The emergency use authorization of two mRNA vaccines in less than a year from the emergence of SARS-CoV-2 represents a landmark in vaccinology^1,2. Yet, how mRNA vaccines stimulate the immune system to elicit prot...

Prabhu S. Arunachalam, Madeleine K. D. Scott, Thomas Hagan, Chunfeng Li… in Nature (2021)

Article

Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial

In a phase 1 randomized, single-center clinical trial, inactivated influenza virus vaccine delivered through dissolvable microneedle patches (MNPs) was found to be safe and immunogenic. Here, we compare the hu...

Nadine G. Rouphael, Lilin Lai, Sonia Tandon, Michele Paine McCullough… in npj Vaccines (2021)

Article

SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung

There is a great need for the development of vaccines that induce potent and long-lasting protective immunity against SARS-CoV-2. Multimeric display of the antigen combined with potent adjuvant can enhance the...

Nanda Kishore Routhu, Narayanaiah Cheedarla… in Nature Communications (2021)

Article

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

The development of a portfolio of COVID-19 vaccines to vaccinate the global population remains an urgent public health imperative¹. Here we demonstrate the capacity of a subunit vaccine, comprising the SARS-CoV-2...

Prabhu S. Arunachalam, Alexandra C. Walls, Nadia Golden, Caroline Atyeo… in Nature (2021)