5 Result(s)

Article

Author Correction: Systems vaccinology of the BNT162b2 mRNA vaccine in humans

Prabhu S. Arunachalam, Madeleine K. D. Scott, Thomas Hagan, Chunfeng Li… in Nature (2023)

Article

Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive responses to BNT162b2 in mice, and show...

Chunfeng Li, Audrey Lee, Lilit Grigoryan, Prabhu S. Arunachalam… in Nature Immunology (2022)

Article

A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice

Adjuvants hold great potential in enhancing vaccine efficacy, making the understanding and improving of adjuvants critical goals in vaccinology. The TLR7/8 agonist, 3M-052, induces long-lived humoral immunity ...

Audrey Lee, Madeleine K. D. Scott, Florian Wimmers… in Nature Communications (2022)

Article

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

The emergency use authorization of two mRNA vaccines in less than a year from the emergence of SARS-CoV-2 represents a landmark in vaccinology^1,2. Yet, how mRNA vaccines stimulate the immune system to elicit prot...

Prabhu S. Arunachalam, Madeleine K. D. Scott, Thomas Hagan, Chunfeng Li… in Nature (2021)

Article

T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers

Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques wit...

Prabhu S. Arunachalam, Tysheena P. Charles, Vineet Joag… in Nature Medicine (2020)