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Open AccessThe effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study
Older age could be a risk factor for suboptimal CD4+ T-cell recovery in HIV-infected patients despite successful viral suppression. However, evaluation of this effect could be confounded by age-related immune ...
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Article
Bone Loss Among Women Living With HIV
Clinical data accumulated over the past two decades attests to a significant decline in bone mineral density (BMD) in patients infected by HIV, which does not remit but may actually intensify with anti-retrovi...
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Article
Role of T-cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss
HIV infection causes bone loss. We previously reported that immunosuppression-mediated B-cell production of receptor activator of NF-κB ligand (RANKL) coupled with decline in osteoprotegerin correlate with dec...
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Article
Enhancing SIV-specific immunity in vivo by PD-1 blockade
Blockade of PD-1 (programmed death-1), a B7/CD28 family immune-receptor molecule that inhibits the immune response to chronic viral infections, is shown to improve anti-viral immune responses in SIV-infected m...
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Article
Open AccessPrimary HIV-1 Infection Sets the Stage for Important B Lymphocyte Dysfunctions