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Article
Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines
Immune imprinting is a phenomenon in which prior antigenic experiences influence responses to subsequent infection or vaccination1,2. The effects of immune imprinting on serum antibody responses after boosting wi...
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Open AccessThree immunizations with Novavax’s protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2
The immune responses to Novavax’s licensed NVX-CoV2373 nanoparticle Spike protein vaccine against SARS-CoV-2 remain incompletely understood. Here, we show in rhesus macaques that immunization with Matrix-MTM adju...
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Article
Open AccessFrom a genome-wide screen of RNAi molecules against SARS-CoV-2 to a validated broad-spectrum and potent prophylaxis
Expanding the arsenal of prophylactic approaches against SARS-CoV-2 is of utmost importance, specifically those strategies that are resistant to antigenic drift in Spike. Here, we conducted a screen of over 16...
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Open AccessBreadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine
Coronavirus vaccines that are highly effective against current and anticipated SARS-CoV-2 variants are needed to control COVID-19. We previously reported a receptor-binding domain (RBD)-sortase A-conjugated fe...
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Open AccessSARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
The recent emergence of B.1.1.529, the Omicron variant1,2, has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their...
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Open AccessA SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge
The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of vaccine protection. We evaluated whether a SARS-CoV-2 spike ferritin nanoparticle vaccine (SpFN), adjuvanted with the Army Li...
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mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates
B.1.351 is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant most resistant to antibody neutralization. We demonstrate how the dose and number of immunizations influence protection. Nonh...
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SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution
SARS-CoV-2 variants of interest and concern will continue to emerge for the duration of the COVID-19 pandemic. To map mutations in the receptor-binding domain (RBD) of the spike protein that affect binding to ...
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Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses
Betacoronaviruses caused the outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome, as well as the current pandemic of SARS coronavirus 2 (SARS-CoV-2)1–4. Vaccines that elicit...
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Article
Performance on patterned string problems by common marmosets (Callithrix jacchus)
This experiment examined the performance of common marmosets (Callithrix jacchus) on a series of patterned string problems to assess the marmosets’ understanding of means–ends relationships. One marmoset, Jet, wa...
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Article
Characteristics of implicit chaining in cotton-top tamarins (Saguinus oedipus)
In human cognition there has been considerable interest in observing the conditions under which subjects learn material without explicit instructions to learn. In the present experiments, we adapted this issue...
