2,203 Result(s)

Article

Activation of Ventral Tegmental Area Dopaminergic Neurons Projecting to the Parabrachial Nucleus Promotes Emergence from Propofol Anesthesia in Male Rats

Since the clinical introduction of general anesthesia, its underlying mechanisms have not been fully elucidated. The ventral tegmental area (VTA) and parabrachial nucleus (PBN) play pivotal roles in the mechan...

Lei Jia, Jieting Yin, Tielong Liu, Wenqiang Qi, Tongyu Du… in Neurochemical Research (2024)

Article

Angelica sinensis polysaccharides promote extramedullary stress erythropoiesis via ameliorating splenic glycolysis and EPO/STAT5 signaling-regulated macrophages

Conventional treatments exhibit various side effects on chronic stress anemia. Extramedullary stress erythropoiesis is a compensatory mechanism, which may effectively counteract anemia. Angelica sinensis polys...

Nianci Sun, Ziling Wang, Honghui Jiang, Biyao Wang… in Journal of Molecular Histology (2024)

Article

Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist

Lele Tao, Dongxue Wang, Qingning Yuan, Fenghui Zhao, Yu Zhang, Tianyuan Du… in Cell Research (2024)

Article

Stable inhibition of choroidal neovascularization by adeno-associated virus 2/8-vectored bispecific molecules

Neovascular age-related macular degeneration (nAMD) causes severe visual impairment. Pigment epithelium-derived factor (PEDF), soluble CD59 (sCD59), and soluble fms-like tyrosine kinase-1 (sFLT-1) are potentia...

Tinghui Bai, Bohao Cui, Man **ng, Siyue Chen, Yanfang Zhu, Dongxue Lin… in Gene Therapy (2024)

Article

Mendelian Randomization Identifies Genetically Supported Drug Targets for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Currently, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have no effective treatments. Drug repurposing offers a rapid method to meet therapeutic need for ALS and FTD. To identify thera...

Yahui Zhu, Mao Li, Hongfen Wang, Fei Yang, RongRong Du… in Molecular Neurobiology (2024)

Article

Neural Differentiation and spinal cord organoid generation from induced pluripotent stem cells (iPSCs) for ALS modelling and inflammatory screening

C9orf72 genetic mutation is the most common genetic cause of ALS/FTD accompanied by abnormal protein insufficiency. Induced pluripotent stem cell (iPSC)-derived two-dimensional (2D) and three-dimensional (3D) ...

Ruiyun Guo, Yimeng Chen, **yu Zhang, Zi**g Zhou, Baofeng Feng… in Molecular Neurobiology (2024)

Article

PMAIP1 regulates autophagy in osteoblasts via the AMPK/mTOR pathway in osteoporosis

Osteoporosis (OP) is a highly prevalent disorder characterized by low bone mass that severely reduces patient quality of life. Although numerous treatments for OP have been introduced in clinic, many have side...

Yijie Gao, Anquan Huang, Yantao Zhao, Yunxia Du in Human Cell (2024)

Article

The Role of Iron Metabolism in Sepsis-associated Encephalopathy: a Potential Target

Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction secondary to infection, and the severity can range from mild delirium to deep coma. Disorders of iron metabolism have been proven to play...

Yinuo Liu, Shengnan Hu, Bowen Shi, Bodong Yu, Wei Luo… in Molecular Neurobiology (2024)

Article

Identification of HSP70 genes in Diaphorina citri Kuwayama Reveals Their Involvement in Immunity and Development

Huanglongbing (HLB), a global citrus threat, is transmitted by Diaphorina citri Kuwayama, a widespread insect pest. The disease’s rapid spread and incurability necessitate efficient, sustainable control strategie...

Ruimin Li, Yimin Du, Yan Zhou, Zhigang Ouyang in Molecular Biotechnology (2024)

Article

Ketogenic Diets Alter the Gut Microbiome, Resulting in Decreased Susceptibility to and Cognitive Impairment in Rats with Pilocarpine-Induced Status Epilepticus

A ketogenic diet (KD) is a high-fat, low-carbohydrate, and low-protein diet that exerts antiepileptic effects by attenuating spontaneous recurrent seizures, ameliorating learning and memory impairments, and mo...

Bianli Li, Yue Ma, Xuhui Wang, Di Zhao, Ziqin Wang, Guoyang Wang… in Neurochemical Research (2024)

Article

Desktop-Stereolithography 3D Printing of a Decellularized Extracellular Matrix/Mesenchymal Stem Cell Exosome Bioink for Vaginal Reconstruction

3D-printing is widely used in regenerative medicine and is expected to achieve vaginal morphological restoration and true functional reconstruction. Mesenchymal stem cells-derived exosomes (MSCs-Exos) were app...

Wenxin Shi, Jiahua Zheng, **gkun Zhang… in Tissue Engineering and Regenerative Medici… (2024)

Article

Microglia and Astrocytes Responses Contribute to Alleviating Inflammatory Damage by Repetitive Transcranial Magnetic Stimulation in Rats with Traumatic Brain Injury

Repetitive transcranial magnetic stimulation (rTMS) is a therapeutic strategy that shows promise in ameliorating the clinical sequelae following traumatic brain injury (TBI). These improvements are associated ...

FangFang Qian, RenHong He, **aoHui Du, Yi Wei, Zhou Zhou… in Neurochemical Research (2024)

Article

The Role of HSP90 Molecular Chaperones in Depression: Potential Mechanisms

Major depressive disorder (MDD) is characterized by high rates of disability and death and has become a public health problem that threatens human life and health worldwide. HPA axis disorder and neuroinflamma...

Xuyuan Fan, Lei Sun, Ye Qin, Yuan Liu, Shusheng Wu, Longfei Du in Molecular Neurobiology (2024)